Built-in functional selectivity in neurons is mediated by the neuronal protein, GINIP
- PMID: 37478823
- DOI: 10.1016/j.molcel.2023.06.034
Built-in functional selectivity in neurons is mediated by the neuronal protein, GINIP
Abstract
In this issue of Molecular Cell, Park et al.1 comprehensively profile how neurons utilize the Gα inhibitory interacting protein, GINIP, to modulate neurotransmission at a systems level through bias of downstream G protein-coupled receptor (GPCR) signaling.
Copyright © 2023 Elsevier Inc. All rights reserved.
Conflict of interest statement
Declaration of Interests The authors declare no competing interests.
Comment on
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Fine-tuning GPCR-mediated neuromodulation by biasing signaling through different G protein subunits.Mol Cell. 2023 Jul 20;83(14):2540-2558.e12. doi: 10.1016/j.molcel.2023.06.006. Epub 2023 Jun 29. Mol Cell. 2023. PMID: 37390816 Free PMC article.
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