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Comment
. 2023 Jul 20;83(14):2395-2397.
doi: 10.1016/j.molcel.2023.06.022.

The promoter as a trip navigator: Guiding alternative polyadenylation site destinations

Alexandra Bergfort  1 , Karla M Neugebauer  2
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Comment

The promoter as a trip navigator: Guiding alternative polyadenylation site destinations

Alexandra Bergfort et al. Mol Cell. .
Free article

Abstract

Alfonso-Gonzalez et al.1 present an innovative combination of long-read-sequencing approaches that reveal coupling of alternative transcription start sites and alternative polyadenylation site usage on a global level.

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Conflict of interest statement

Declaration of interests The authors declare no competing interests.

Comment on

  • Sites of transcription initiation drive mRNA isoform selection.
    Alfonso-Gonzalez C, Legnini I, Holec S, Arrigoni L, Ozbulut HC, Mateos F, Koppstein D, Rybak-Wolf A, Bönisch U, Rajewsky N, Hilgers V. Alfonso-Gonzalez C, et al. Cell. 2023 May 25;186(11):2438-2455.e22. doi: 10.1016/j.cell.2023.04.012. Epub 2023 May 12. Cell. 2023. PMID: 37178687 Free PMC article.

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