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Editorial
. 2023 Aug 8;122(15):3019-3021.
doi: 10.1016/j.bpj.2023.07.005. Epub 2023 Jul 20.

Unveiling the intricacies of intracellular Ca2+ regulation in the heart

Charlotte E R Smith  1 , Eleonora Grandi  2
Affiliations
Editorial

Unveiling the intricacies of intracellular Ca2+ regulation in the heart

Charlotte E R Smith et al. Biophys J. .

Abstract

Recent studies have provided valuable insight into the key mechanisms contributing to the spatiotemporal regulation of intracellular Ca2+ release and Ca2+ signaling in the heart. In this research highlight, we focus on the latest findings published in Biophysical Journal examining the structural organization of Ca2+ handling proteins and assessing the functional aspects of intracellular Ca2+ regulation in health and the detrimental consequences of Ca2+ dysregulation in disease. These important studies pave the way for future mechanistic investigations and multiscale understanding of Ca2+ signaling in the heart.

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Figures

Figure 1
Figure 1
Spatial and temporal scales involved in intracellular Ca2+ regulation in the heart.
See this image and copyright information in PMC

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