Stage lighting on PAR-1: a step further in the understanding of acquired focal and segmental glomerulosclerosis
- PMID: 37479383
- DOI: 10.1016/j.kint.2023.04.016
Stage lighting on PAR-1: a step further in the understanding of acquired focal and segmental glomerulosclerosis
Abstract
The pathogenic mechanisms of acquired focal and segmental glomerular sclerosis are only partially known and represent a medical challenge in nephrology. The article by May et al. sheds additional light on previous data indicating the key role of the protease-activated receptor 1. The new evidence is based on in vivo studies in relevant animal models and on patient biopsies and represents a significant step forward in the understanding of this pathologic condition.
Copyright © 2023 International Society of Nephrology. Published by Elsevier Inc. All rights reserved.
Comment on
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Podocyte protease activated receptor 1 stimulation in mice produces focal segmental glomerulosclerosis mirroring human disease signaling events.Kidney Int. 2023 Aug;104(2):265-278. doi: 10.1016/j.kint.2023.02.031. Epub 2023 Mar 20. Kidney Int. 2023. PMID: 36940798 Free PMC article.
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