Comment
doi: 10.1016/j.kint.2023.05.011.
One antigen closer to understanding membranous nephropathy
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- PMID: 37479386
- DOI: 10.1016/j.kint.2023.05.011
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Comment
One antigen closer to understanding membranous nephropathy
Kidney Int.
2023 Aug.
Abstract
Membranous nephropathy is an immune-mediated kidney disease characterized by subepithelial immune deposits. Through the utilization of advanced proteomic techniques, multiple target antigens have been identified, including those associated with primary and secondary etiologies. Nonsteroidal anti-inflammatory drugs represent an important secondary cause of membranous nephropathy. In this study by Sethi et al., advanced proteomic techniques identify proprotein convertase subtilisin/kexin type 6 as a target antigen in nonsteroidal anti-inflammatory drug-associated membranous nephropathy.
Copyright © 2023 International Society of Nephrology. Published by Elsevier Inc. All rights reserved.
Comment on
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Proprotein convertase subtilisin/kexin type 6 (PCSK6) is a likely antigenic target in membranous nephropathy and nonsteroidal anti-inflammatory drug use.Kidney Int. 2023 Aug;104(2):343-352. doi: 10.1016/j.kint.2023.04.006. Epub 2023 Apr 28. Kidney Int. 2023. PMID: 37119877
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