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Meta-Analysis
. 2023 Jul 21;13(1):11826.
doi: 10.1038/s41598-023-38603-x.

Effect of aerobic and resistance exercise training on endothelial function in individuals with overweight and obesity: a systematic review with meta-analysis of randomized clinical trials

Maiquel Bueno Cortes #  1 , Raphael Silveira Nunes da Silva #  1 , Patrícia Caetano de Oliveira #  1 , Diego Silveira da Silva  1 , Maria Claudia Costa Irigoyen #  1   2 , Gustavo Waclawovsky #  1 , Maximiliano Isoppo Schaun #  3   4
Affiliations
Meta-Analysis

Effect of aerobic and resistance exercise training on endothelial function in individuals with overweight and obesity: a systematic review with meta-analysis of randomized clinical trials

Maiquel Bueno Cortes et al. Sci Rep. .

Abstract

The objective of this systematic review was to examine the effects of exercise training on endothelial function in individuals with overweight and obesity. Our review study included only randomized controlled trials (RCTs) involving adults (≥ 18 years of age) with body mass index (BMI) ≥ 25.0 kg/m2. Our search was conducted in the electronic bases MEDLINE (PubMed), Cochrane, LILACS and EMBASE and in the gray literature. We performed random-effects analyses for effect estimates and used 95% prediction intervals (95% PI) for estimating the uncertainty of the study results. There were selected 10 RCTs involving 14 groups (n = 400). The quality assessment of studies using Cochrane risk-of-bias 2 (RoB 2) tool identified some concerns. Exercise training resulted in improved flow-mediated dilation (FMD) in individuals with overweight and obesity (p < 0.001) compared to the no-exercise control group. This effect of training modalities on FMD was seen for aerobic training (p < 0.001) but not for resistance training (p = 0.051). There was no difference in FMD in response to exercise training by BMI classification (overweight, obesity, overweight + obesity), p = 0.793. The present results are consistent with the notion that aerobic exercise training elicits favorable adaptations in endothelial function in individuals with overweight and obesity. Our findings should be interpreted with caution because of the small number of studies included in this review.

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Conflict of interest statement

The authors declare no competing interests.

Figures

Figure 1
Figure 1
Flow chart summarizing the study selection process.
Figure 2
Figure 2
Quality of the body of evidence (GRADE quality rating) for the effect of exercise training in individuals with overweight and obesity.
Figure 3
Figure 3
Quality of the body of evidence (GRADE quality rating) for the effect of aerobic training in individuals with overweight and obesity.
Figure 4
Figure 4
Quality of the body of evidence (GRADE quality rating) for the effect of resistance training in individuals with overweight and obesity.
Figure 5
Figure 5
Risk of bias assessment using Cochrane’s risk-of-bias 2 (RoB 2) tool. FMD, flow-mediated dilation.
Figure 6
Figure 6
Forest plot for the pooled mean effect of exercise training and for subgroup (aerobic, resistance) versus no-exercise in individuals with overweight and obesity. HITT high-intensity interval training, MICT moderate-intensity continuous training, RT resistance training.
Figure 7
Figure 7
Forest plot for the pooled mean effect of exercise training and for subgroup (overweight, obesity and overweight + obesity) versus no-exercise in individuals with overweight and obesity. HITT high-intensity interval training, MICT moderate-intensity continuous training, RT resistance training.
See this image and copyright information in PMC

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