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. 2023 Nov;38(11):1380-1385.
doi: 10.1007/s00380-023-02293-2. Epub 2023 Jul 21.

Clinical characteristics of tetralogy of Fallot with left pulmonary artery acute angulation on computed tomography

Seung Chan Ym  1 , Ki Seok Choo  2 , Kyoung Jin Nam  1 , Kyeyoung Lee  1 , Jae-Yeon Hwang  1 , ChanKue Park  1 , Kwang Ho Choi  3
Affiliations

Clinical characteristics of tetralogy of Fallot with left pulmonary artery acute angulation on computed tomography

Seung Chan Ym et al. Heart Vessels. 2023 Nov.

Abstract

Left pulmonary artery (LPA) stenosis with acute angulation commonly necessitates surgical revision in the treatment of tetralogy of Fallot (TOF). We investigated the clinical characteristics of acute angulation of the LPA in patients with TOF via computed tomography (CT). Between 2011 and 2022, 160 patients were diagnosed with TOF using CT. After excluding 28 patients due to insufficient records or age, 132 patients were included in the present analysis. The patients were divided into two groups according to the presence or absence of acute angulation of the LPA: group I (TOF with an acute angle of the LPA, n = 53) and group II (TOF without an acute angle of the LPA, n = 79). We retrospectively collected clinical data from electronic medical records. T-tests were used to analyze continuous variables (i.e., age, sex, weight, right ventricular outflow tract [RVOT] pressure on echocardiography, and distance to bifurcation), and Fisher's exact and chi-square tests were used to analyze categorical data (i.e., presence of the right aortic arch, pulmonary arterial atresia/hypoplasia, atrial septal defect [ASD], patent ductus arteriosus [PDA], and pulmonary valve). The groups did not differ significantly in terms of sex, weight, presence of the right aortic arch, pulmonary arterial atresia/hypoplasia, ASD, or distance to the bifurcation. Moreover, there was no significant difference between the presence and absence of PDA (P = 0.057); however, patients in group I were significantly older (143.2 ± 97.8 days) than those in group II (91.1 ± 76.0 days, P = 0.002). Furthermore, RVOT pressure was significantly higher among patients in group I (45.1 ± 22.5 mmHg) than in group II (25.0 ± 12.4 mmHg, P < 0.001). In the current study, acute angulation of the LPA in patients with TOF, as observed on CT, was associated with older age and higher RVOT pressure on echocardiography.

Keywords: Acute angulation; Cyanotic congenital heart disease; Image analysis; MDCT, LPA stenosis; RVOT pressure gradient; Tetralogy of Fallot.

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References

    1. Reller MD, Strickland MJ, Riehle-Colarusso T, Mahle WT, Correa A (2008) Prevalence of congenital heart defects in metropolitan Atlanta, 1998–2005. J Pediatr 153(6):807–813 - DOI - PubMed - PMC
    1. Bertranou EG, Blackstone EH, Hazelrig JB, Turner ME, Kirklin JW (1978) Life expectancy without surgery in tetralogy of Fallot. Am J Cardiol 42(3):458–466 - DOI - PubMed
    1. Mulder BJM (2012) Epidemiology of adult congenital heart disease: demographic variations worldwide. Neth Heart J 20(12):505–508 - DOI - PubMed - PMC
    1. Anderson RH, Jacobs ML (2008) The anatomy of tetralogy of Fallot with pulmonary stenosis. Cardiol Young 18(Suppl 3):12–21 - DOI - PubMed
    1. Zubairi R, Dhillon R, Kovach JR (2011) Risk factors for prosthesis failure in pulmonary valve replacement. Ann Thorac Surg 91(2):561–565 - DOI - PubMed

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