Structure elucidation of Keroplatus (Diptera:Keroplatidae) fungus gnat oxyluciferin

Affiliations

¹ Shemyakin-Ovchinnikov Institute of Bioorganic Chemistry of the Russian Academy of Sciences, 16/10 Miklukho-Maklaya str., Moscow, 117997, Russia. Electronic address: alexey_kotlobay@ibch.ru.
² Shemyakin-Ovchinnikov Institute of Bioorganic Chemistry of the Russian Academy of Sciences, 16/10 Miklukho-Maklaya str., Moscow, 117997, Russia; Department of Biological and Medical Physics, Moscow Institute of Physics and Technology (State University), 9 Institutskiy per., Dolgoprudny, Moscow, 141700, Russia.
³ Shemyakin-Ovchinnikov Institute of Bioorganic Chemistry of the Russian Academy of Sciences, 16/10 Miklukho-Maklaya str., Moscow, 117997, Russia.
⁴ Shemyakin-Ovchinnikov Institute of Bioorganic Chemistry of the Russian Academy of Sciences, 16/10 Miklukho-Maklaya str., Moscow, 117997, Russia; Higher Chemical College of the Russian Academy of Sciences, D. Mendeleev University of Chemical Technology of Russia, 9 Miusskaya sq., Moscow, 125047, Russia.
⁵ Shemyakin-Ovchinnikov Institute of Bioorganic Chemistry of the Russian Academy of Sciences, 16/10 Miklukho-Maklaya str., Moscow, 117997, Russia; Faculty of Chemistry, National Research University Higher School of Economics, 7 Vavilova str., Moscow, 119048, Russia.
⁶ Department of Chemistry, Connecticut College, New London, CT, 06320, USA.
⁷ Shemyakin-Ovchinnikov Institute of Bioorganic Chemistry of the Russian Academy of Sciences, 16/10 Miklukho-Maklaya str., Moscow, 117997, Russia; Institute of Translational Medicine, Pirogov Russian National Research Medical University, 1 Ostrovityanova str., Moscow, 117997, Russia.
⁸ Shemyakin-Ovchinnikov Institute of Bioorganic Chemistry of the Russian Academy of Sciences, 16/10 Miklukho-Maklaya str., Moscow, 117997, Russia; Institute of Translational Medicine, Pirogov Russian National Research Medical University, 1 Ostrovityanova str., Moscow, 117997, Russia. Electronic address: zkaskova@ibch.ru.

PMID: 37480687
DOI: 10.1016/j.bbrc.2023.07.035

Structure elucidation of Keroplatus (Diptera:Keroplatidae) fungus gnat oxyluciferin

Alexey A Kotlobay et al. Biochem Biophys Res Commun. 2023.

. 2023 Oct 8:676:1-5.

doi: 10.1016/j.bbrc.2023.07.035. Epub 2023 Jul 17.

Affiliations

¹ Shemyakin-Ovchinnikov Institute of Bioorganic Chemistry of the Russian Academy of Sciences, 16/10 Miklukho-Maklaya str., Moscow, 117997, Russia. Electronic address: alexey_kotlobay@ibch.ru.
² Shemyakin-Ovchinnikov Institute of Bioorganic Chemistry of the Russian Academy of Sciences, 16/10 Miklukho-Maklaya str., Moscow, 117997, Russia; Department of Biological and Medical Physics, Moscow Institute of Physics and Technology (State University), 9 Institutskiy per., Dolgoprudny, Moscow, 141700, Russia.
³ Shemyakin-Ovchinnikov Institute of Bioorganic Chemistry of the Russian Academy of Sciences, 16/10 Miklukho-Maklaya str., Moscow, 117997, Russia.
⁴ Shemyakin-Ovchinnikov Institute of Bioorganic Chemistry of the Russian Academy of Sciences, 16/10 Miklukho-Maklaya str., Moscow, 117997, Russia; Higher Chemical College of the Russian Academy of Sciences, D. Mendeleev University of Chemical Technology of Russia, 9 Miusskaya sq., Moscow, 125047, Russia.
⁵ Shemyakin-Ovchinnikov Institute of Bioorganic Chemistry of the Russian Academy of Sciences, 16/10 Miklukho-Maklaya str., Moscow, 117997, Russia; Faculty of Chemistry, National Research University Higher School of Economics, 7 Vavilova str., Moscow, 119048, Russia.
⁶ Department of Chemistry, Connecticut College, New London, CT, 06320, USA.
⁷ Shemyakin-Ovchinnikov Institute of Bioorganic Chemistry of the Russian Academy of Sciences, 16/10 Miklukho-Maklaya str., Moscow, 117997, Russia; Institute of Translational Medicine, Pirogov Russian National Research Medical University, 1 Ostrovityanova str., Moscow, 117997, Russia.
⁸ Shemyakin-Ovchinnikov Institute of Bioorganic Chemistry of the Russian Academy of Sciences, 16/10 Miklukho-Maklaya str., Moscow, 117997, Russia; Institute of Translational Medicine, Pirogov Russian National Research Medical University, 1 Ostrovityanova str., Moscow, 117997, Russia. Electronic address: zkaskova@ibch.ru.

PMID: 37480687
DOI: 10.1016/j.bbrc.2023.07.035

Abstract

Bioluminescence of insects is a well-known natural phenomenon in the focus of interest of scientific research. While the mechanisms of bioluminescence in Coleoptera have been extensively studied, there is a lack of information about the chemistry of light emission in Diptera species. Here we report the Keroplatus spp. oxyluciferin structure elucidation and identification as 3-hydroxykynurenic acid. Additionally, the present study provides the first direct evidence of the relationship between the bioluminescent systems of Orfelia and Keroplatus. However, the properties of the putative Orfelia oxyluciferin suggest that the light emission mechanisms are not identical.

Keywords: Bioluminescence; Keroplatidae; Keroplatus; NMR spectroscopy; Orfelia fultoni; Oxyluciferin.

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Declaration of competing interest The authors declare that they have no known competing financial interests or personal relationships that could have appeared to influence the work reported in this paper

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Structure elucidation of Keroplatus (Diptera:Keroplatidae) fungus gnat oxyluciferin

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Structure elucidation of Keroplatus (Diptera:Keroplatidae) fungus gnat oxyluciferin

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Abstract

Conflict of interest statement

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