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. 2023 Nov;165(5):1197-1205.e2.
doi: 10.1053/j.gastro.2023.07.003. Epub 2023 Jul 20.

Incidence, Prevalence, and Racial and Ethnic Distribution of Inflammatory Bowel Disease in the United States

James D Lewis  1 , Lauren E Parlett  2 , Michele L Jonsson Funk  3 , Colleen Brensinger  4 , Virginia Pate  3 , Qufei Wu  4 , Ghadeer K Dawwas  4 , Alexandra Weiss  5 , Brad D Constant  6 , Maureen McCauley  4 , Kevin Haynes  7 , Jeff Yufeng Yang  3 , Douglas E Schaubel  8 , Andres Hurtado-Lorenzo  9 , Michael David Kappelman  10
Affiliations

Incidence, Prevalence, and Racial and Ethnic Distribution of Inflammatory Bowel Disease in the United States

James D Lewis et al. Gastroenterology. 2023 Nov.

Abstract

Background & aims: We sought to estimate the incidence, prevalence, and racial-ethnic distribution of physician-diagnosed inflammatory bowel disease (IBD) in the United States.

Methods: The study used 4 administrative claims data sets: a 20% random sample of national fee-for-service Medicare data (2007 to 2017); Medicaid data from Florida, New York, Pennsylvania, Ohio, and California (1999 to 2012); and commercial health insurance data from Anthem beneficiaries (2006 to 2018) and Optum's deidentified Clinformatics Data Mart (2000 to 2017). We used validated combinations of medical diagnoses, diagnostic procedures, and prescription medications to identify incident and prevalent diagnoses. We computed pooled age-, sex-, and race/ethnicity-specific insurance-weighted estimates and pooled estimates standardized to 2018 United States Census estimates with 95% confidence intervals (CIs).

Results: The age- and sex-standardized incidence of IBD per 100,000 person-years was 10.9 (95% CI, 10.6-11.2). The incidence of IBD peaked in the third decade of life, decreased to a relatively stable level across the fourth to eighth decades, and declined further. The age-, sex- and insurance-standardized prevalence of IBD was 721 per 100,000 population (95% CI, 717-726). Extrapolated to the 2020 United States Census, an estimated 2.39 million Americans are diagnosed with IBD. The prevalence of IBD per 100,000 population was 812 (95% CI, 802-823) in White, 504 (95% CI, 482-526) in Black, 403 (95% CI, 373-433) in Asian, and 458 (95% CI, 440-476) in Hispanic Americans.

Conclusions: IBD is diagnosed in >0.7% of Americans. The incidence peaks in early adulthood and then plateaus at a lower rate. The disease is less commonly diagnosed in Black, Asian, and Hispanic Americans.

Keywords: Crohn’s Disease; Epidemiology; Medicaid; Medicare; Race; Ulcerative Colitis.

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Figures

Figure 1.
Figure 1.
Age- and sex-specific incidence per 100,000 person-years (A) IBD, (B) ulcerative colitis and (C) Crohn’s disease in the United States
Figure 2.
Figure 2.
Age- and sex-specific prevalence per 100,000 population of (A) IBD, (B) ulcerative colitis and (C) Crohn’s disease in the United States
Figure 3.
Figure 3.
Age- and sex-adjusted prevalence of IBD, ulcerative colitis and Crohn’s disease by race and ethnicity (A) and region (B)
See this image and copyright information in PMC

Comment in

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