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. 2023 Dec;32(12):3417-3426.
doi: 10.1007/s11136-023-03479-x. Epub 2023 Jul 22.

Translation and validation of a Chinese version of the pancreatitis quality of life instrument (PANQOLI) in patients with chronic pancreatitis

Jia-Yun Chen #  1   2 , Yuan-Chen Wang #  1   3 , Hui-Jun Xi #  4 , Hong Tao  1 , Qi Zhao  1 , Meng-Ting Yu  1 , Lei Xin  1 , Liang-Hao Hu  1 , Qian He  5 , Wen-Bin Zou  6   7 , You-Qing Peng  8
Affiliations

Translation and validation of a Chinese version of the pancreatitis quality of life instrument (PANQOLI) in patients with chronic pancreatitis

Jia-Yun Chen et al. Qual Life Res. 2023 Dec.

Abstract

Purpose: Chronic pancreatitis (CP) is a chronic fibroinflammatory pancreatic disease that severely impacts patients' quality of life (QoL). The Pancreatitis Quality of Life Instrument (PANQOLI) is an 18-item measure specifically designed to assess QoL amongst patients with CP. This study aimed to develop a Chinese version of PANQOLI and assess its reliability and validity in the Chinese CP cohort.

Methods: Translation was performed according to forward-backwards translation steps and transcultural adaptation. Five hundred Mandarin Chinese-speaking patients with CP were enrolled, 250 for the exploratory factor analysis (EFA) and 250 for the confirmatory factor analysis (CFA). Item analysis, reliability analysis (internal consistency, split-half reliability, test-retest reliability), and validity analysis (content validity, construct validity, and convergent validity) were performed.

Results: Item analysis of the Chinese version of PANQOLI revealed that the absolute t values of all items were > 3. Reliability analysis showed that Cronbach's α coefficient was 0.868, split-half coefficient was 0.934, and intraclass correlation coefficient was 0.859, demonstrating excellent reliability. For content validity, item level content validity index (I-CVI) ranged from 0.8 to 1.0, and average of I-CVI scores across all items (S-CVI/Ave) was 0.91. In construct validity analysis, EFA produced four dimensions after rotation, and results of CFA showed χ2/df = 2.346, comparative fit index (CFI) = 0.929, Tucker-Lewis index (TLI) = 0.915, and root-mean-square error of approximation (RMSEA) = 0.074. The analysis of convergent validity indicated that the Chinese version of PANQOLI was moderately correlated with the physical (r = 0.436, P < 0.001) and mental component summary (r = 0.518, P < 0.001) of the 36-Item Short Form Health Survey.

Conclusion: The Chinese version of PANQOLI appears to be culturally appropriate, reliable, and valid for assessing the QoL amongst Chinese patients with CP.

Keywords: Chronic pancreatitis; PANQOLI; Reliability; Translation; Validity.

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References

    1. Gardner, T. B., Adler, D. G., Forsmark, C. E., Sauer, B. G., Taylor, J. R., & Whitcomb, D. C. (2020). ACG clinical guideline: Chronic pancreatitis. American Journal of Gastroenterology, 115(3), 322–339. https://doi.org/10.14309/ajg.0000000000000535 - DOI - PubMed
    1. Beyer, G., Habtezion, A., Werner, J., Lerch, M. M., & Mayerle, J. (2020). Chronic pancreatitis. Lancet, 396(10249), 499–512. https://doi.org/10.1016/s0140-6736(20)31318-0 - DOI - PubMed
    1. Vege, S. S., & Chari, S. T. (2022). Chronic Pancreatitis. New England Journal of Medicine, 386(9), 869–878. https://doi.org/10.1056/NEJMcp1809396 - DOI - PubMed
    1. Oh, T. K., & Song, I. A. (2020). Five-year mortality trends associated with chronic pancreatitis in South Korea: A population based cohort study. Pancreatology, 20(5), 828–833. https://doi.org/10.1016/j.pan.2020.04.024 - DOI - PubMed
    1. Zou, W. B., Ru, N., Wu, H., Hu, L. H., Ren, X., Jin, G., Wang, Z., Du, Y. Q., Cao, Y. N., Zhang, L., & Chang, X. Y. (2019). Guidelines for the diagnosis and treatment of chronic pancreatitis in China (2018 edition). Hepatobiliary and Pancreatic Diseases International, 18(2), 103–109. https://doi.org/10.1016/j.hbpd.2019.02.004 - DOI - PubMed

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