Skip to main page content
U.S. flag

An official website of the United States government

Dot gov

The .gov means it’s official.
Federal government websites often end in .gov or .mil. Before sharing sensitive information, make sure you’re on a federal government site.

Https

The site is secure.
The https:// ensures that you are connecting to the official website and that any information you provide is encrypted and transmitted securely.

Access keys NCBI Homepage MyNCBI Homepage Main Content Main Navigation
Comment
. 2023 Aug 2;31(8):2304-2306.
doi: 10.1016/j.ymthe.2023.07.007. Epub 2023 Jul 22.

Bypassing the cytokine sink: IL-2-independent IL-2 receptor signaling

Tim Luetkens  1
Affiliations
Comment

Bypassing the cytokine sink: IL-2-independent IL-2 receptor signaling

Tim Luetkens. Mol Ther. .
No abstract available

PubMed Disclaimer

Conflict of interest statement

Declaration of interests The author declares no conflict of interest.

Figures

Figure 1
Figure 1
Schema of engineering approaches for selective IL2R signaling
See this image and copyright information in PMC

Comment on

References

    1. Cook P.J., Yang S.J., Uenishi G.I., Grimm A., West S.E., Wang L.-J., Jacobs C., Repele A., Drow T., Boukhris A., et al. A chemically inducible IL-2 receptor signaling complex allows for effective in vitro and in vivo selection of engineered CD4+ T cells. Mol. Ther. 2023 doi: 10.1016/j.ymthe.2023.04.021. - DOI - PMC - PubMed
    1. Hippen K.L., Hefazi M., Larson J.H., Blazar B.R. Emerging translational strategies and challenges for enhancing regulatory T cell therapy for graft-versus-host disease. Front. Immunol. 2022;13 doi: 10.3389/fimmu.2022.926550. - DOI - PMC - PubMed
    1. Cappell K.M., Kochenderfer J.N. Long-term outcomes following CAR T cell therapy: what we know so far. Nat. Rev. Clin. Oncol. 2023;20:359–371. doi: 10.1038/s41571-023-00754-1. - DOI - PMC - PubMed
    1. Gattinoni L., Finkelstein S.E., Klebanoff C.A., Antony P.A., Palmer D.C., Spiess P.J., Hwang L.N., Yu Z., Wrzesinski C., Heimann D.M., et al. Removal of homeostatic cytokine sinks by lymphodepletion enhances the efficacy of adoptively transferred tumor-specific CD8+ T cells. J. Exp. Med. 2005;202:907–912. doi: 10.1084/jem.20050732. - DOI - PMC - PubMed
    1. Kochenderfer J.N., Yu Z., Frasheri D., Restifo N.P., Rosenberg S.A. Adoptive transfer of syngeneic T cells transduced with a chimeric antigen receptor that recognizes murine CD19 can eradicate lymphoma and normal B cells. Blood. 2010;116:3875–3886. doi: 10.1182/blood-2010-01-265041. - DOI - PMC - PubMed

MeSH terms

LinkOut - more resources