Skip to main page content
U.S. flag

An official website of the United States government

Dot gov

The .gov means it’s official.
Federal government websites often end in .gov or .mil. Before sharing sensitive information, make sure you’re on a federal government site.

Https

The site is secure.
The https:// ensures that you are connecting to the official website and that any information you provide is encrypted and transmitted securely.

Access keys NCBI Homepage MyNCBI Homepage Main Content Main Navigation
Review
. 2023 Jul 19:14:20417314231187956.
doi: 10.1177/20417314231187956. eCollection 2023 Jan-Dec.

Tissue engineering in growth plate cartilage regeneration: Mechanisms to therapeutic strategies

Ruoyi Guo  1 , Hanjie Zhuang  1 , Xiuning Chen  1 , Yulong Ben  1 , Minjie Fan  1 , Yiwei Wang  1 , Pengfei Zheng  1
Affiliations
Review

Tissue engineering in growth plate cartilage regeneration: Mechanisms to therapeutic strategies

Ruoyi Guo et al. J Tissue Eng. .

Abstract

The repair of growth plate injuries is a highly complex process that involves precise spatiotemporal regulation of multiple cell types. While significant progress has been made in understanding the pathological mechanisms underlying growth plate injuries, effectively regulating this process to regenerate the injured growth plate cartilage remains a challenge. Tissue engineering technology has emerged as a promising therapeutic approach for achieving tissue regeneration through the use of functional biological materials, seed cells and biological factors, and it is now widely applied to the regeneration of bone and cartilage. However, due to the unique structure and function of growth plate cartilage, distinct strategies are required for effective regeneration. Thus, this review provides an overview of current research on the application of tissue engineering to promote growth plate regeneration. It aims to elucidates the underlying mechanisms by which tissue engineering promotes growth plate regeneration and to provide novel insights and therapeutic strategies for future research on the regeneration of growth plate.

Keywords: Biomaterials; growth plate injury; regeneration; tissue engineering.

PubMed Disclaimer

Conflict of interest statement

The author(s) declared no potential conflicts of interest with respect to the research, authorship, and/or publication of this article.

Figures

Figure 1.
Figure 1.
The overview of growth plate cartilage regeneration strategy. The pathological mechanisms and conventional treatment methods following growth plate injuries are presented, and the significant role of tissue engineering in the growth plates regeneration is revealed.
Figure 2.
Figure 2.
The process of bone bridge formation after growth plate injury and related events. After the growth plate injury, cells and biological factors change dynamically with the progress of pathological process, and eventually lead to the bone bridge formation.
Figure 3.
Figure 3.
FoxA2+ LTSSC maintain cartilage homeostasis by contributing to long-term self-renewal, chondrogenic differentiation and cartilage repair after injury. SOC = secondary ossification center. Image from Muruganandan et al. 2022 (open-access article distributed under the terms of the Creative Commons Attribution Licence, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited).
Figure 4.
Figure 4.
The overview of the tissue engineering for growth plate regeneration.
See this image and copyright information in PMC

References

    1. Newton PT, Li L, Zhou B, et al.A radical switch in clonality reveals a stem cell niche in the epiphyseal growth plate. Nature 2019; 567: 234–238. - PubMed
    1. Samsa WE, Zhou X, Zhou G.Signaling pathways regulating cartilage growth plate formation and activity. Semin Cell Dev Biol 2017; 62: 3–15. - PMC - PubMed
    1. Kazemi M, Williams JL.Properties of cartilage-subchondral bone junctions: a narrative review with specific focus on the growth plate. Cartilage 2021; 13: 16S–33S. - PMC - PubMed
    1. Qiao Z, Lian M, Han Y, et al.Bioinspired stratified electrowritten fiber-reinforced hydrogel constructs with layer-specific induction capacity for functional osteochondral regeneration. Biomaterials 2021; 266: 120385. - PubMed
    1. Dua K, Abzug JM, Sesko Bauer A, et al.Pediatric distal radius fractures. Instr Course Lect 2017; 66: 447–460. - PubMed

LinkOut - more resources