Skip to main page content
U.S. flag

An official website of the United States government

Dot gov

The .gov means it’s official.
Federal government websites often end in .gov or .mil. Before sharing sensitive information, make sure you’re on a federal government site.

Https

The site is secure.
The https:// ensures that you are connecting to the official website and that any information you provide is encrypted and transmitted securely.

Access keys NCBI Homepage MyNCBI Homepage Main Content Main Navigation
. 2023 Jun 22;15(6):e40803.
doi: 10.7759/cureus.40803. eCollection 2023 Jun.

Factors Affecting Platelet-Rich Plasma Success in Patients With Diabetic Foot Ulcer

Eyüp Murat Kanber  1 , Harun Gulmez  2
Affiliations

Factors Affecting Platelet-Rich Plasma Success in Patients With Diabetic Foot Ulcer

Eyüp Murat Kanber et al. Cureus. .

Abstract

Introduction Diabetic foot ulcers (DFU) are one of the most common complications of diabetes mellitus (DM). The use of platelet-rich plasma (PRP) in the treatment of DFU has been increasing in recent years. In the current study, we aimed to evaluate the factors affecting the success of PRP in the management of DFU. Methods The present study was planned in a prospective manner, and we enrolled patients with DFU in the study. Patients' characteristics, DFU properties, and treatment outcomes were recorded. Patients with DFU were classified into two groups according to PRP success: healed DFU patients in Group 1 and non-healed DFU patients in Group 2. Groups were compared according to patient characteristics and treatment outcomes, and multivariate regression analysis was performed to clarify factors that predicted PRP success. Results In total, 182 patients were enrolled in the study, and DFU in 141 (77.5%) patients healed with PRP treatment. The mean body mass index (BMI) was significantly higher in the non-healed patients (p= 0.005). The smoking rate was 58.5% in the non-healed group and 39.7% in the healed group (p= 0.016). The duration of DM (17.9 years vs. 22.5 years, p= 0.003) was significantly longer, and patients with glomerular filtration rate (GFR) < 60 (44.0% vs. 63.4, p= 0.028) were significantly more common in the non-healed group. Multivariate regression analysis demonstrated that BMI ≥30 kg/m2 and duration of DM ≥20 years were predictive factors for PRP failure in patients with DFU (p= 0.019 and p= 0.005). Smoking and GFR <60 were significantly associated with PRP failure (p= 0.040 and p= 0.044). Conclusion In our study, it was found that PRP was an effective treatment that improved DFU in 141 out of 182 patients. Moreover, the present study demonstrated for the first time that higher BMI, longer duration of DM, smoking, and lower GFR were significantly related to PRP failure in patients with DFU.

Keywords: diabetes mellitus; diabetic foot ulcer; glomerular filtration rate; obesity; prp; smoking.

PubMed Disclaimer

Conflict of interest statement

The authors have declared that no competing interests exist.

Figures

Figure 1
Figure 1. PRP preparation scheme
PRP: platelet-rich plasma; PPP: platelet-poor plasma
Figure 2
Figure 2. Example pictures of patients (Figure 2a: healed, Figure 2b: non-healed)
See this image and copyright information in PMC

References

    1. Diabetes mellitus statistics on prevalence and mortality: facts and fallacies. Zimmet P, Alberti KG, Magliano DJ, Bennett PH. Nat Rev Endocrinol. 2016;12:616–622. - PubMed
    1. Cost-effectiveness analysis for the treatment of diabetic foot ulcer in France: platelet-rich plasma vs standard of care. Russo S, Landi S, Courric S. Clinicoecon Outcomes Res. 2022;14:1–10. - PMC - PubMed
    1. A cost-effectiveness analysis comparing single-use and traditional negative pressure wound therapy to treat chronic venous and diabetic foot ulcers. Kirsner RS, Delhougne G, Searle RJ. https://pubmed.ncbi.nlm.nih.gov/32294054/ Wound Manag Prev. 2020;66:30–36. - PubMed
    1. Cost-effectiveness of platelet-rich plasma for diabetic foot ulcer in Spain. Linertová R, Del Pino-Sedeño T, Pérez LG, et al. Int J Low Extrem Wounds. 2021;20:119–127. - PubMed
    1. Efficacy and safety of autologous platelet-rich plasma for diabetic foot ulcer healing: a systematic review and meta-analysis of randomized controlled trials. Deng J, Yang M, Zhang X, Zhang H. J Orthop Surg Res. 2023;18:370. - PMC - PubMed

LinkOut - more resources