Itch, sleep loss, depressive symptoms, fatigue, and productivity loss in patients with moderate-to-severe atopic dermatitis: Analyses of TREATgermany registry data

Thomas Birkner^#¹, Doreen Siegels^#¹, Luise Heinrich¹, Eva Haufe¹, Susanne Abraham², Annice Heratizadeh³, Inken Harder⁴, Magnus Bell⁵, Isabell Fell⁶, Margitta Worm⁷, Christiane Handrick⁸, Isaak Effendy⁹, Andrea Asmussen¹⁰, Andreas Kleinheinz¹¹, Bernhard Homey¹², Michael Sticherling¹³, Sung-Hei Hong-Weldemann¹⁴, Matthias Augustin¹⁵, Elke Weisshaar¹⁶, Knut Schäkel¹⁷, Thomas Schaefer¹⁸, Beate Schwarz¹⁹, Franca Wiemers²⁰, Jens-Joachim Brücher²¹, Sven Quist²², Andreas Wollenberg²³, Tilo Biedermann²⁴, Konstantin Ertner²⁵, Ralph von Kiedrowski²⁶, Thomas Werfel^#³, Stephan Weidinger^#⁴, Jochen Schmitt^#¹; the TREATgermany Study Group

Affiliations

¹ Center of Evidence-Based Healthcare, University Hospital Carl Gustav Carus and Carl Gustav Carus Faculty of Medicine, Technische Universität Dresden, Dresden, Germany.
² Department of Dermatology, University Allergy Center, Carl Gustav Carus Faculty of Medicine, Technische Universität Dresden, Dresden, Germany.
³ Department of Dermatology and Allergy, Hannover Medical School, Hannover, Germany.
⁴ Center for Inflammatory Skin Diseases, Department of Dermatology and Allergy, University Hospital Schleswig-Holstein Campus Kiel, Kiel, Germany.
⁵ Practice Dr. med. Magnus Bell, Andernach, Germany.
⁶ Hautmedizin Bad Soden Studienzentrum, Bad Soden, Germany.
⁷ Department of Dermatology, Allergy and Venereology, Charité - Universitätsmedizin Berlin, Berlin, Germany.
⁸ Practice Dr. med. Christiane Handrick, Berlin, Germany.
⁹ Department of Dermatology, OWL University Hospital of Bielefeld University, Campus Clinic Bielefeld, Bielefeld, Germany.
¹⁰ Practice Dr. med. Andrea Asmussen, Dermatology at Lesum, Bremen, Germany.
¹¹ Clinics for Dermatology, Elbe Klinikum, Buxtehude, Germany.
¹² Department of Dermatology and Allergology, University Hospital Duesseldorf, Düsseldorf, Germany.
¹³ Department of Dermatology, University, German Center for Immunotherapy, Erlangen, Germany.
¹⁴ Practice Dr. med. Sung-Hei Hong-Weldemann, Freiburg im Breisgau, Germany.
¹⁵ Institute for Health Services Research in Dermatology Hamburg, University Medical Center Hamburg Eppendorf, Hamburg, Germany.
¹⁶ Division of Occupational Dermatology, Department of Dermatology, Ruprecht-Karls University, Heidelberg, Germany.
¹⁷ Department of Dermatology, University Hospital, Heidelberg, Germany.
¹⁸ Practice Dr. med. Thomas Schaefer/ Dr. med. Doreen Belz, Derma Koeln, Köln, Germany.
¹⁹ Practice Dr. med. Beate Schwarz, Langenau, Germany.
²⁰ Practice Dr. med. Franca Wiemers, Leipzig, Germany.
²¹ Practice Dr. med. Jens-Joachim Brücher, Hautambulatorium Magdeburg, Magdeburg, Germany.
²² Dermatology Clinic, Helix Medical Excellence Center Mainz, Mainz, Germany.
²³ Clinics and Outpatient Clinics for Dermatology and Allergy, LMU Munich, München, Germany and Vrije Universiteit Brussel, Universitair Ziekenhuis, Department of Dermatology, Brussels, Belgium.
²⁴ Department of Dermatology and Allergy, School of Medicine, Technical University of Munich, München, Germany.
²⁵ Practice Dr. med. Konstantin Ertner, Nürnberg, Germany.
²⁶ Focus Practice for chronic inflammatory dermatoses, skin cancer and allergology and also Study Center CMS3 (Company for Medical Study and Service), Selters/Westerwald, Germany.

^# Contributed equally.

PMID: 37485573
DOI: 10.1111/ddg.15159

Multicenter Study

Itch, sleep loss, depressive symptoms, fatigue, and productivity loss in patients with moderate-to-severe atopic dermatitis: Analyses of TREATgermany registry data

Thomas Birkner et al. J Dtsch Dermatol Ges. 2023 Oct.

. 2023 Oct;21(10):1157-1168.

doi: 10.1111/ddg.15159. Epub 2023 Jul 23.

Authors

Affiliations

¹ Center of Evidence-Based Healthcare, University Hospital Carl Gustav Carus and Carl Gustav Carus Faculty of Medicine, Technische Universität Dresden, Dresden, Germany.
² Department of Dermatology, University Allergy Center, Carl Gustav Carus Faculty of Medicine, Technische Universität Dresden, Dresden, Germany.
³ Department of Dermatology and Allergy, Hannover Medical School, Hannover, Germany.
⁴ Center for Inflammatory Skin Diseases, Department of Dermatology and Allergy, University Hospital Schleswig-Holstein Campus Kiel, Kiel, Germany.
⁵ Practice Dr. med. Magnus Bell, Andernach, Germany.
⁶ Hautmedizin Bad Soden Studienzentrum, Bad Soden, Germany.
⁷ Department of Dermatology, Allergy and Venereology, Charité - Universitätsmedizin Berlin, Berlin, Germany.
⁸ Practice Dr. med. Christiane Handrick, Berlin, Germany.
⁹ Department of Dermatology, OWL University Hospital of Bielefeld University, Campus Clinic Bielefeld, Bielefeld, Germany.
¹⁰ Practice Dr. med. Andrea Asmussen, Dermatology at Lesum, Bremen, Germany.
¹¹ Clinics for Dermatology, Elbe Klinikum, Buxtehude, Germany.
¹² Department of Dermatology and Allergology, University Hospital Duesseldorf, Düsseldorf, Germany.
¹³ Department of Dermatology, University, German Center for Immunotherapy, Erlangen, Germany.
¹⁴ Practice Dr. med. Sung-Hei Hong-Weldemann, Freiburg im Breisgau, Germany.
¹⁵ Institute for Health Services Research in Dermatology Hamburg, University Medical Center Hamburg Eppendorf, Hamburg, Germany.
¹⁶ Division of Occupational Dermatology, Department of Dermatology, Ruprecht-Karls University, Heidelberg, Germany.
¹⁷ Department of Dermatology, University Hospital, Heidelberg, Germany.
¹⁸ Practice Dr. med. Thomas Schaefer/ Dr. med. Doreen Belz, Derma Koeln, Köln, Germany.
¹⁹ Practice Dr. med. Beate Schwarz, Langenau, Germany.
²⁰ Practice Dr. med. Franca Wiemers, Leipzig, Germany.
²¹ Practice Dr. med. Jens-Joachim Brücher, Hautambulatorium Magdeburg, Magdeburg, Germany.
²² Dermatology Clinic, Helix Medical Excellence Center Mainz, Mainz, Germany.
²³ Clinics and Outpatient Clinics for Dermatology and Allergy, LMU Munich, München, Germany and Vrije Universiteit Brussel, Universitair Ziekenhuis, Department of Dermatology, Brussels, Belgium.
²⁴ Department of Dermatology and Allergy, School of Medicine, Technical University of Munich, München, Germany.
²⁵ Practice Dr. med. Konstantin Ertner, Nürnberg, Germany.
²⁶ Focus Practice for chronic inflammatory dermatoses, skin cancer and allergology and also Study Center CMS3 (Company for Medical Study and Service), Selters/Westerwald, Germany.

^# Contributed equally.

PMID: 37485573
DOI: 10.1111/ddg.15159

Abstract

Background: TREATgermany is a multicenter registry including patients with moderate-to-severe atopic dermatitis (AD) from currently 74 study centers (university clinics, hospitals and practices) in Germany. As of August 31, 2021, 1,230 adult patients were enrolled.

Methods: In TREATgermany, patients and physicians fill in questionnaires pertaining to symptoms, disease severity, quality of life, depressiveness, and fatigue. In particular, limitations in work performance are assessed using the Work Limitations Questionnaire (WLQ). To assess associations between occupational performance/work limitations and symptoms, correlations and regression models were calculated.

Results: The examined sample of 228 employed patients reported an average of 6% at-work productivity loss within the past two weeks prior to enrolment in the registry. The WLQ productivity loss score was moderately associated with itch (r = 0.32) and sleep loss (r = 0.39) and strongly associated with depressive symptoms (r = 0.68) and fatigue (r = 0.60).

Conclusions: The analyses of the registry data show that moderate-to-severe atopic dermatitis has a negative impact on the work productivity of the patients. The analyses further point out the relevant associations between work productivity, depressive symptoms, and fatigue highlighting the disease burden caused by the psychological components of AD.

Keywords: Atopic dermatitis; productivity loss; registry; work limitations.

PubMed Disclaimer

References

REFERENCES

1. Langan SM, Irvine AD, Weidinger S. Atopic dermatitis. Lancet. 2020;396:345-360.
1. Siegels D, Heratizadeh A, Abraham S, et al. Systemic treatments in the management of atopic dermatitis: A systematic review and meta-analysis. Allergy. 2021;76:1053-1076.
1. Zietze HA, Cabral C, Theobald K, et al. Epidemiology and treatment of adult patients with atopic dermatitis : Analysis of longitudinal data of the statutory health insurance scheme. Hautarzt. 2021;72:963-974.
1. Gilaberte Y, Pérez-Gilaberte JB, Poblador-Plou B, et al. Prevalence and comorbidity of atopic dermatitis in children: a large-scale population study based on real-world data. J Clin Med. 2020;9:1632.
1. Stingeni L, Belloni Fortina A, Baiardini I, et al. Atopic dermatitis and patient perspectives: insights of bullying at school and career discrimination at work. J Asthma Allergy 2021;14:919-928.

Publication types

Actions
Actions

MeSH terms

Actions
Actions
Actions
Actions
Actions
Actions
Actions
Actions
Actions
Actions
Actions
Actions
Actions

LinkOut - more resources

Full Text Sources
- Ovid Technologies, Inc.
- Wiley
Research Materials
- NCI CPTC Antibody Characterization Program
Miscellaneous
- NCI CPTAC Assay Portal

Save citation to file

Email citation

Add to Collections

Add to My Bibliography

Your saved search

Create a file for external citation management software

Your RSS Feed

Itch, sleep loss, depressive symptoms, fatigue, and productivity loss in patients with moderate-to-severe atopic dermatitis: Analyses of TREATgermany registry data

Affiliations

Itch, sleep loss, depressive symptoms, fatigue, and productivity loss in patients with moderate-to-severe atopic dermatitis: Analyses of TREATgermany registry data

Authors

Affiliations

Abstract

References

REFERENCES

Publication types

MeSH terms

LinkOut - more resources

Full Text Sources

Research Materials

Miscellaneous