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. 2023 Aug;29(8):1634-1637.
doi: 10.3201/eid2908.230472.

Chromosome-Borne CTX-M-65 Extended-Spectrum β-Lactamase-Producing Salmonella enterica Serovar Infantis, Taiwan

Ying-Shu Liao, Hsiao-Lun Wei, Hung-Chih Kuo, Bo-Han Chen, You-Wun Wang, Ru-Hsiou Teng, Yu-Ping Hong, Jui-Hsien Chang, Shiu-Yun Liang, Chi-Sen Tsao, Chien-Shun Chiou

Chromosome-Borne CTX-M-65 Extended-Spectrum β-Lactamase-Producing Salmonella enterica Serovar Infantis, Taiwan

Ying-Shu Liao et al. Emerg Infect Dis. 2023 Aug.

Abstract

A CTX-M-65‒producing Salmonella enterica serovar Infantis clone, probably originating in Latin America and initially reported in the United States, has emerged in Taiwan. Chicken meat is the most likely primary carrier. Four of the 9 drug resistance genes have integrated into the chromosome: blaCTX-M-65, tet(A), sul1, and aadA1.

Keywords: CTX-M-65; DNA transposable elements; Salmonella enterica; Taiwan; bacteria; chickens; chromosome; chromosome-borne; extended-spectrum β-lactamase; multidrug resistance; plasmid; serovar Infantis.

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Figures

Figure 1
Figure 1
Core genome multilocus sequence typing tree and relevant information for investigation of chromosome-borne CTX-M-65 extended-spectrum β-lactamase–producing Salmonella enterica serovar Infantis, Taiwan. The cluster highlighted in red consists of blaCTX-M-65–carrying strains. GenBank accession numbers are shown. ID, identification.
Figure 2
Figure 2
Genetic map of plasmid pN16S097 from investigation of chromosome-borne CTX-M-65 extended-spectrum β-lactamase–producing Salmonella enterica serovar Infantis, Taiwan. The locations of antimicrobial drug resistance genes and insertion sequence IS26 are indicated. A 125-kb segment, depicted by a blue solid arc, is translocated into the chromosomes of blaCTX-M-65–carrying Salmonella Infantis strains emerging in Taiwan.
See this image and copyright information in PMC

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