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. 2024 May;34(3):1131-1137.
doi: 10.1007/s10895-023-03345-6. Epub 2023 Jul 24.

Synthesis and Fluorescence Properties of Imidazopyridine-Linked Coumarins via Tandem C(sp2)-H Functionalization/Decarboxylation Reaction

Seyyed Emad Hooshmand  1 , Zahra Amini  1 , Morteza Shiri  2 , Ahmed Al-Harrasi  3
Affiliations

Synthesis and Fluorescence Properties of Imidazopyridine-Linked Coumarins via Tandem C(sp2)-H Functionalization/Decarboxylation Reaction

Seyyed Emad Hooshmand et al. J Fluoresc. 2024 May.

Abstract

A catalyst-, oxidant-free and green synthetic route for direct access to a series of novel imidazopyridine-linked coumarins has been devised through tandem C(sp2)-H functionalization/decarboxylation reaction in ethyl acetate as a sustainable medium. Moreover, the utilities of ensured products in further organic synthesis were conducted by Suzuki-Miyaura and Sonogashira cross-coupling reactions. The fluorescence characteristics of the produced molecules are appropriate, and the synthesized scaffolds could promisingly garner future attention in clinical diagnostics and bioimaging research.

Keywords: Catalyst-free syntheses; Coumarins; C–H functionalization; Decarboxylation reactions; Fluorescence molecules; Imidazopyridine.

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