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Comment
. 2023 Aug;120(31):e2311001120.
doi: 10.1073/pnas.2311001120. Epub 2023 Jul 24.

Antitoxins within toxins: A new theme in bacterial antivirus defense

Eugene V Koonin  1
Affiliations
Comment

Antitoxins within toxins: A new theme in bacterial antivirus defense

Eugene V Koonin. Proc Natl Acad Sci U S A. 2023 Aug.
No abstract available

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Conflict of interest statement

The author declares no competing interest.

Figures

Fig. 1.
Fig. 1.
A gene within gene yields the antitoxin in a bacterial TA system. iTIS, internal translation initiation site; (4 aa)n denotes the hypervariable four amino acid repeats in RpnS. The C-terminal domain of RpnL corresponding to RpnS is shown in dark red, and the free RpnS translated from the iTIS is shown in yellow. The active toxin appears to be an RpnL dimer, and the inhibition of the nuclease activity involves RpnS binding to each of the monomers. The mechanism of RpnS release triggered by phage infection (?) remains to be elucidated.
See this image and copyright information in PMC

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