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. 2023 Sep;22(9):103393.
doi: 10.1016/j.autrev.2023.103393. Epub 2023 Jul 22.

Posttranslational modifications in psoriatic arthritis: A systematic literature review

Omar-Javier Calixto  1 , Maria-Alejandra Meneses-Toro  2 , Edward-Camilo Vera-Parra  2 , Juan-Manuel Bello-Gualtero  2 , Consuelo Romero-Sanchez  3 , Sandra J Perdomo  4
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Free article

Posttranslational modifications in psoriatic arthritis: A systematic literature review

Omar-Javier Calixto et al. Autoimmun Rev. 2023 Sep.
Free article

Abstract

Background and aims: Psoriatic arthritis (PsA) is an inflammatory complex condition. Posttranslational modifications influence almost all aspects of normal cell biology and pathogenesis. The aim of this systematic review was to collect all published evidence regarding posttranslational modifications in PsA, and the main outcome was to evaluate an association between disease outcomes and specific posttranslational modifications in PsA.

Methods: A systematic electronic search was performed in Medline, PubMed, Cochrane, Virtual Health Library, and Embase databases. A total of 587 articles were identified; 59 were evaluated after removing duplicates and scanning, of which 47 were included. A descriptive analysis was conducted, with results grouped according to the type of posttranslational modification evaluated. The protocol was registered at the PROSPERO database.

Results: Seven posttranslational modifications were identified: citrullination, carbamylation, phosphorylation, glycosylation, acetylation, methylation, and oxidative stress. Anti-citrullinated peptide and anti-carbamylated protein have been evaluated in rheumatoid arthritis. There is now information suggesting that these antibodies may be helpful in improving the diagnosis of PsA and that they may demonstrate a correlation with worse disease progression (erosions, polyarticular involvement, and poor treatment response). Glycosylation was associated with increased inflammation and phosphorylation products related to the expression of SIRT2 and pSTAT3 or the presence of Th17 and cytokine interleukin-22, suggesting a possible therapeutic target.

Conclusions: Posttranslational modifications often play a key role in modulating protein function in PsA and correlate with disease outcomes. Citrullination, carbamylation, phosphorylation, glycosylation, acetylation, methylation, and oxidative stress were identified as associated with diagnosis and prognosis.

Keywords: Carbamylation; Citrullination; Glycosylation; Phosphorylation; Posttranslational modifications; Psoriatic arthritis.

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Conflict of interest statement

Declaration of Competing Interest The authors declare that the research was conducted in the absence of any commercial or financial relationships that could be construed as a potential conflict of interest.

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