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. 2023 Oct:386:129545.
doi: 10.1016/j.biortech.2023.129545. Epub 2023 Jul 23.

Whole-cell synthesis of 2,5-furandicarboxylic acid from pineapple waste under various fermentation strategies

Rajendran Omana Rajesh  1 , Nalinakshan Sreevidya Shruthy  2 , Santhamma Akhila  3 , Tharangattumana Krishnan Godan  1 , Nair R Dileep  4 , Júlio César de Carvalho  5 , Luciana Porto de Souza Vandenberghe  5 , Carlos Ricardo Soccol  5 , Raveendran Sindhu  6 , Parameswaran Binod  7
Affiliations

Whole-cell synthesis of 2,5-furandicarboxylic acid from pineapple waste under various fermentation strategies

Rajendran Omana Rajesh et al. Bioresour Technol. 2023 Oct.

Abstract

2,5-Furandicarboxylic acid (FDCA) is one of the platform chemicals and monomers used in plastic industries, currently synthesized by carcinogenic and toxic chemical processes with high pressure and temperature. The aim of this study was to develop a bioprocess for the production of FDCA. 5-(Hydroxymethyl)furfural (HMF) was synthesized (22.67 ± 1.36 g/l/h) from pineapple peel using chromium(III) chloride (CrCl3) at 100 °C. After optimization, approximately 3 mg/l/h FDCA was produced by Aspergillus flavus APLS-1 from HMF in a 2.5 L fermenter in a batch strategy. Parallel and immobilized packed bad bioreactors showed less production of FDCA. A fed-batch strategy produced 3.5 ± 0.3 mg/l/h of FDCA in shake flasks. Also, approximately 0.55 mg/l/h of FDCA was produced from pineapple waste derived HMF. However, these bioprocesses may be improved to increase the yield of renewable FDCA, in the future. This is the first report on FDCA production from pineapple waste.

Keywords: 2,5-Furandicarboxylic acid; 5-(Hydroxymethyl)furfural; Aspergillus flavus; Bioprocess; Fermentation; Pineapple waste.

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Conflict of interest statement

Declaration of Competing Interest The authors declare that they have no known competing financial interests or personal relationships that could have appeared to influence the work reported in this paper.

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