Skip to main page content
U.S. flag

An official website of the United States government

Dot gov

The .gov means it’s official.
Federal government websites often end in .gov or .mil. Before sharing sensitive information, make sure you’re on a federal government site.

Https

The site is secure.
The https:// ensures that you are connecting to the official website and that any information you provide is encrypted and transmitted securely.

Access keys NCBI Homepage MyNCBI Homepage Main Content Main Navigation
Comment
. 2023 Sep;33(9):653-654.
doi: 10.1038/s41422-023-00857-5.

Lactylation regulates cardiac function

Shohini Ghosh-Choudhary  1 , Toren Finkel  2
Affiliations
Comment

Lactylation regulates cardiac function

Shohini Ghosh-Choudhary et al. Cell Res. 2023 Sep.
No abstract available

PubMed Disclaimer

Figures

Fig. 1
Fig. 1. Schematic diagram showing a mechanistic model of α-MHC lactylation in the heart.
Lactylation, a novel PTM, occurs on a specific lysine residue of the α-MHC. This PTM alters the interaction of myosin with titin, thereby modulating cardiac contractility. Levels of lactate are reduced in the failing heart, perhaps due to elevated consumption of this metabolite. The generation of lactate is catalyzed by the enzyme LDHA, while efflux of this metabolite occurs through the transporter MCT4. The small molecule VB124 can inhibit the export of lactate from cells, thereby increasing intracellular levels of this metabolite and potentially aiding the failing heart.
See this image and copyright information in PMC

Comment on

References

    1. Dorn GW., 2nd Biochim. Biophys. Acta. 2013;1833:233–241. doi: 10.1016/j.bbamcr.2012.03.008. - DOI - PMC - PubMed
    1. Zhang, N. et al. Cell Res. 10.1038/s41422-023-00844-w (2023).
    1. Wang M, Lin H. Annu. Rev. Biochem. 2021;90:245–285. doi: 10.1146/annurev-biochem-082520-125411. - DOI - PubMed
    1. Herzog H. Biophys. Rev. 2018;10:1187–1199. doi: 10.1007/s12551-017-0395-y. - DOI - PMC - PubMed
    1. Zhang D, et al. Nature. 2019;574:575–580. doi: 10.1038/s41586-019-1678-1. - DOI - PMC - PubMed

LinkOut - more resources