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Comment
. 2023 Sep;33(9):651-652.
doi: 10.1038/s41422-023-00855-7.

Unveiling the hidden battlefield: dissecting the invasive zone in liver cancer

Valerie Chew  1
Affiliations
Comment

Unveiling the hidden battlefield: dissecting the invasive zone in liver cancer

Valerie Chew. Cell Res. 2023 Sep.
No abstract available

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Figures

Fig. 1
Fig. 1. Schematic summary of findings from Wu et al. on invasive margin in liver cancer.
a Study design with combination of Stereo-seq and scRNA-seq to examine tumor (T), margin (M), paratumor (P) and lymph node (LN) tissues from 21 patients with liver cancer. Notably, Stereo-seq has sub-cellular resolution with detection spot at 220 nm diameter (45× smaller than the diameter of a typical single cell, 25 µm) and the spot-to-spot distance of 500–750 nm. b Main findings on the tumor invasive margin, a 500 µm zone centered around tumor border. c Validation of the clinical impact of SAAs in 4 cohorts of patients with primary or secondary liver cancers (n = 423). Additional validation of the role of SAAs in mouse liver tumor models orthotopically implanted with SAAs-knockdown cell lines.
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