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Comment
. 2023 Aug;38(8):1397-1398.
doi: 10.1002/mds.29555. Epub 2023 Jul 25.

Blood-Based α-Synuclein Seeding-A New Era for Identifying Parkinsonian Syndromes

Max Borsche  1   2 , Daniela Berg  3
Affiliations
Comment

Blood-Based α-Synuclein Seeding-A New Era for Identifying Parkinsonian Syndromes

Max Borsche et al. Mov Disord. 2023 Aug.
No abstract available

Keywords: Parkinson's disease; multiple system atrophy; serum biomarker; synucleinopathies; α-synuclein seeding assay.

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Comment on

  • Propagative α-synuclein seeds as serum biomarkers for synucleinopathies.
    Okuzumi A, Hatano T, Matsumoto G, Nojiri S, Ueno SI, Imamichi-Tatano Y, Kimura H, Kakuta S, Kondo A, Fukuhara T, Li Y, Funayama M, Saiki S, Taniguchi D, Tsunemi T, McIntyre D, Gérardy JJ, Mittelbronn M, Kruger R, Uchiyama Y, Nukina N, Hattori N. Okuzumi A, et al. Nat Med. 2023 Jun;29(6):1448-1455. doi: 10.1038/s41591-023-02358-9. Epub 2023 May 29. Nat Med. 2023. PMID: 37248302 Free PMC article.

References

    1. Bloem BR, Okun MS, Klein C. Parkinson's disease. Lancet 2021;397:2284-2303.
    1. Yoo D, Bang J-I, Ahn C, et al. Diagnostic value of α-synuclein seeding amplification assays in α-synucleinopathies: a systematic review and meta-analysis. Parkinsonism Relat Disord 2022;104:99-109.
    1. Siderowf A, Concha-Marambio L, Lafontant D-E, et al. Assessment of heterogeneity among participants in the Parkinson's Progression Markers Initiative cohort using α-synuclein seed amplification: a cross-sectional study. Lancet Neurol 2023;22:407-417.
    1. Kluge A, Bunk J, Schaeffer E, et al. Detection of neuron-derived pathological α-synuclein in blood. Brain 2022;145:3058-3071.
    1. Okuzumi A, Hatano T, Matsumoto G, et al. Propagative α-synuclein seeds as serum biomarkers for synucleinopathies. Nat Med 2023;29:1448-1455.

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