Thiamine for Septic Shock: Take Your Vitamins?

Tomoko Fujii^{1

2}, Jonathan Sevransky^{3

4}

Affiliations

¹ Intensive Care Unit Jikei University Hospital Tokyo, Japan.
² Australian and New Zealand Intensive Care Research Centre Monash University School of Public Health and Preventive Medicine Melbourne, Victoria, Australia.
³ Division of Pulmonary, Allergy, Critical Care, and Sleep Emory University Atlanta, Georgia.
⁴ Emory Critical Care Center Emory Healthcare Atlanta, Georgia.

Editorial

Tomoko Fujii et al. Am J Respir Crit Care Med. 2023.

. 2023 Sep 1;208(5):513-515.

doi: 10.1164/rccm.202307-1140ED.

Tomoko Fujii^{1

2}, Jonathan Sevransky^{3

4}

¹ Intensive Care Unit Jikei University Hospital Tokyo, Japan.
² Australian and New Zealand Intensive Care Research Centre Monash University School of Public Health and Preventive Medicine Melbourne, Victoria, Australia.
³ Division of Pulmonary, Allergy, Critical Care, and Sleep Emory University Atlanta, Georgia.
⁴ Emory Critical Care Center Emory Healthcare Atlanta, Georgia.

No abstract available

Comment on

Effect of Thiamine on Clinical Outcomes in Septic Shock Patients: A Randomized, Double-Blinded Pilot Study.
Pereira AG, Costa NA, Amancio SCP, Okoshi MP, Zornoff LAM, Azevedo PS, Minicucci MF, de Paiva SAR, Polegato BF. Pereira AG, et al. Am J Respir Crit Care Med. 2023 Sep 1;208(5):616-618. doi: 10.1164/rccm.202208-1583LE. Am J Respir Crit Care Med. 2023. PMID: 37053464 Clinical Trial. No abstract available.
Thiamine for Renal Protection in Septic Shock (TRPSS): A Randomized, Placebo-controlled, Clinical Trial.
Moskowitz A, Berg KM, Grossestreuer AV, Balaji L, Liu X, Cocchi MN, Chase M, Gong MN, Gong J, Parikh SM, Ngo L, Berlin N, Donnino MW. Moskowitz A, et al. Am J Respir Crit Care Med. 2023 Sep 1;208(5):570-578. doi: 10.1164/rccm.202301-0034OC. Am J Respir Crit Care Med. 2023. PMID: 37364280 Free PMC article. Clinical Trial.

1. Buchman TG, Simpson SQ, Sciarretta KL, Finne KP, Sowers N, Collier M, et al. Sepsis among Medicare beneficiaries: 1. The burdens of sepsis, 2012-2018. Crit Care Med . 2020;48:276–288. - PMC - PubMed
1. Evans L, Rhodes A, Alhazzani W, Antonelli M, Coopersmith CM, French C, et al. Executive summary. Surviving Sepsis Campaign: international guidelines for the management of sepsis and septic shock 2021. Crit Care Med . 2021;49:1974–1982. - PubMed
1. Donnino MW, Carney E, Cocchi MN, Barbash I, Chase M, Joyce N, et al. Thiamine deficiency in critically ill patients with sepsis. J Crit Care . 2010;25:576–581. - PubMed
1. Fujii T, Luethi N, Young PJ, Frei DR, Eastwood GM, French CJ, et al. VITAMINS Trial Investigators Effect of vitamin C, hydrocortisone, and thiamine vs hydrocortisone alone on time alive and free of vasopressor support among patients with septic shock: the VITAMINS randomized clinical trial. JAMA . 2020;323:423–431. - PMC - PubMed
1. Sevransky JE, Rothman RE, Hager DN, Bernard GR, Brown SM, Buchman TG, et al. VICTAS Investigators Effect of vitamin C, thiamine, and hydrocortisone on ventilator- and vasopressor-free days in patients with sepsis: the VICTAS randomized clinical trial. JAMA . 2021;325:742–750. - PMC - PubMed