Skip to main page content
U.S. flag

An official website of the United States government

Dot gov

The .gov means it’s official.
Federal government websites often end in .gov or .mil. Before sharing sensitive information, make sure you’re on a federal government site.

Https

The site is secure.
The https:// ensures that you are connecting to the official website and that any information you provide is encrypted and transmitted securely.

Access keys NCBI Homepage MyNCBI Homepage Main Content Main Navigation
Clinical Trial
. 2023 Jul 25;77(Suppl 2):S206-S210.
doi: 10.1093/cid/ciad323.

Viewpoint: Antimicrobial Resistance Diagnostics Use Accelerator: Qualitative Research on Adherence to Prescriptions

Adélaïde Compaoré  1 , Deborah Ekusai-Sebatta  2 , David Kaawa-Mafigiri  3 , Vida Kukula  4 , Selase Odopey  4 , James Kapisi  2 , Heidi Hopkins  5 , François Kiemde  1 , Halidou Tinto  1 , Rita Baiden  4 , Piero Olliaro  6   7 , Juvenal Nkeramahame  6 , Sabine Dittrich  6   8   9 , Philip Horgan  6   10   11 ; ADIP study group
Collaborators, Affiliations
Clinical Trial

Viewpoint: Antimicrobial Resistance Diagnostics Use Accelerator: Qualitative Research on Adherence to Prescriptions

Adélaïde Compaoré et al. Clin Infect Dis. .

Abstract

In this Viewpoint, the authors explore the determinants of patients' prescription adherence behaviors as part of FIND's Advancing Access to Diagnostic Innovation essential for Universal Health Coverage and AMR Prevention (ADIP) trials (ClinicalTrials.gov identifier: NCT04081051). Research findings from Burkina Faso, Ghana, and Uganda show that basic knowledge and understanding of prescription instructions are essential for adherence and can be improved through better communication. However, there are a range of other factors that influence adherence, some of which can be influenced through tailored communication messages from healthcare workers. These messages may contribute to changes in adherence behavior but may require other reinforcing interventions to be effective. Finally, there are some drivers of nonadherence centered around costs and time pressure that require other forms of intervention.

Keywords: adherence; antibiotic; behaviors; determinants; prescription.

PubMed Disclaimer

Conflict of interest statement

Potential conflicts of interest. P. H. reports research funding from FIND and an honoraria payment from Oxford International Biomedical Centre (OIBC). H. H. reports being employed by the London School of Hygiene and Tropical Medicine; receiving separate financial support from the study sponsors for some work on the project reported in this supplement; salary support from the UK Foreign Commonwealth and Development Office; royalties from UpToDate; a clinical decision support tool from Wolters Kluwer for authorizing and maintaining the chapter on “Laboratory Tools for Diagnosis of Malaria”; honoraria for lecturing for the University of Virginia and for a doctoral thesis review for the University of Otago in New Zealand; and holding index-linked mutual fund and retirement account investments. J. N. reports funding support and consulting fees from FIND. R. B., V. K., and S. O. report funding support and donation of diagnostic kits from FIND. All other authors report no potential conflicts. All authors have submitted the ICMJE Form for Disclosure of Potential Conflicts of Interest. Conflicts that the editors consider relevant to the content of the manuscript have been disclosed.

References

    1. Salami O, Horgan P, Moore CE, et al. Impact of a package of diagnostic tools, clinical algorithm, and training and communication on outpatient acute fever case management in low- and middle-income countries: protocol for a randomized controlled trial. Trials 2020; 21:974. - PMC - PubMed
    1. Ministère de la Santé Burkina Faso (DGESS) . Annuaire statistique 2020. 2021. Available at: https://www.sante.gov.bf/fileadmin/user_upload/storages/annuaire_statist.... Accessed 15 December 2022.
    1. Uganda Bureau of Statistics . Multi-dimensional poverty index for Uganda. Kampala. 2022. Available at: https://www.ubos.org/wp-content/uploads/publications/08_2022Multi_Povert.... Accessed 15 January 2023.
    1. Jin J, Sklar GE, Oh VMS, Li SC. Factors affecting therapeutic compliance: a review from the patient's perspective. Ther Clin Risk Manag 2008; 4:269–86. - PMC - PubMed
    1. Chauke GD, Nakwafila O, Chibi B, Sartorius B, Mashamba-Thompson T. Factors influencing poor medication adherence amongst patients with chronic disease in low-and-middle-income countries: a systematic scoping review. Heliyon 2022; 8:e09716. - PMC - PubMed

Publication types

Substances

Associated data