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. 2023 Jul 25;24(1):611.
doi: 10.1186/s12891-023-06739-6.

Skeletal effects of eccentric strengthening exercise: a scoping review

Harshvardhan Singh  1 , Bethany A Moore  2   3 , Roshita Rathore  4 , William R Reed  2 , William R Thompson  5 , Gordon Fisher  6 , Donald H Lein  2 , Gary R Hunter  3
Affiliations

Skeletal effects of eccentric strengthening exercise: a scoping review

Harshvardhan Singh et al. BMC Musculoskelet Disord. .

Erratum in

Abstract

Background: Conventional progressive concentric strengthening exercise (CSE) to improve bone mineral density (BMD) and bone mineral content (BMC) may not be feasible for populations with chronic musculoskeletal and/or metabolic conditions, such as osteoporosis or obesity. Muscle lengthening exercise, also known as an eccentric strengthening exercise (ESE), may have a special utility for those populations due to greater force generation versus CSE. In fact, greater mechanical loading can be induced on bone at lower resistance levels with ESE. However, effects of ESE on BMD and BMC are unclear. Thus, the purpose of this review was to interrogate the effects of ESE on BMD and BMC.

Methods: A literature review was conducted between January 1995 and April 2022 focusing on randomized controlled trials investigating the effects of ESE on BMD and/or BMC in humans. Terms covering the domains of exercise, bone, and populations were searched on PubMed, CINAHL, and Scopus. The methodological quality of each interventional study was rated using Physiotherapy Evidence Database (PEDro) scale. Cohen's d was calculated to determine the magnitude of the effects of ERE on site-specific outcome measures of BMD and/or BMC.

Results: Out of 1,182 articles initially found, a total of seven full length articles met our inclusion criteria. Of the seven studies, most of the interventions were performed in young (n = 5, PEDro = 5-7) versus middle-aged (n = 1, PEDro = 4) or older (n = 1, PEDro = 6) adults. BMD and BMC generally improved due to ESE; however the effects of ESE on BMD and BMC were non-homogenous. Effect size (d) ranged from 0.10-0.87 in young adults while it was 1.16 in older adults. Effect size (d) could not be calculated for the middle-aged adult study due to critical methodological limitations of the intervention.

Conclusions: Large variability exists for the effectiveness of ESE on BMD/BMC across the human life spectrum. The benefits of ESE on BMD holds promise but rigorous studies are lacking. Further research is needed to examine if the dose, mode, age, and sex-specificity dictate effects of ESE on BMD/BMC.

Keywords: Bone; Eccentric; Exercise; Load; Older.

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Conflict of interest statement

The authors declare no competing interests.

Figures

Fig. 1
Fig. 1
Search terms and strategy (Database used: PubMed, Scopus, CINAHL)
Fig. 2
Fig. 2
Data extraction; CINAHL, Cumulated index to nursing and allied health literature
Fig. 3
Fig. 3
Conceptual diagram; ESE, Eccentric strengthening exercise; OB, Osteoblast; OC, Osteocyte; ECM, Extracellular matrix; HC, Hemichannels; ATP, Adenosine tri phosphate; BMD, Bone mineral density
See this image and copyright information in PMC

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