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Case Reports
. 2023 Jul;44(4):240-243.
doi: 10.4082/kjfm.22.0201. Epub 2023 Jul 18.

A Case of Painful Diplopia after COVID-19 Vaccination: Could It Be Tolosa-Hunt Syndrome?

Wafa Ammari  1 , Alyssa Kammoun  1 , Asma Zaghdoudi  1 , Olfa Berriche  2 , Samia Younes  3 , Riadh Messaoud  1
Affiliations
Case Reports

A Case of Painful Diplopia after COVID-19 Vaccination: Could It Be Tolosa-Hunt Syndrome?

Wafa Ammari et al. Korean J Fam Med. 2023 Jul.

Abstract

Herein, we report a rare case of Tolosa-Hunt syndrome (THS) following coronavirus disease 2019 (COVID-19) vaccine administration. A 64-year-old patient presented with recurrent horizontal diplopia and ipsilateral orbital pain, 2 weeks after being administered the COVID-19 vaccination. A diagnosis of THS was based on the relevant criteria after ruling out the differential diagnoses. The clinical presentation improved with corticosteroid administration. THS must be recognized as a complication of COVID-19 vaccination. This association can be explained by an autoimmune response.

Keywords: Case Report; Corticosteroids; Diplopia; Magnetic Resonance Imaging; Painful Ophthalmoplegia; Tolosa-Hunt Syndrome.

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Conflict of interest statement

CONFLICT OF INTEREST

No potential conflict of interest relevant to this article was reported.

Figures

Figure. 1.
Figure. 1.
Images showing limited abduction in both eyes. Written informed consent for the publication of this image was obtained from the patient.
Figure. 2.
Figure. 2.
Contrast-enhanced T1 coronal image of magnetic resonance angiography showing enhancement of the cavernous sinus suggestive of a granulomatous lesion or Tolosa-Hunt syndrome (arrows).
Figure. 3.
Figure. 3.
Image showing the improvement in ocular mobility 1 month after corticosteroid therapy. Written informed consent for the publication of this image was obtained from the patient.
See this image and copyright information in PMC

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