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Case Reports
. 2023 Jul 23;11(7):e7626.
doi: 10.1002/ccr3.7626. eCollection 2023 Jul.

Ten-year follow-up report and neurologic sequelae in a case of neonatal severe primary hyperparathyroidism

Nahid Khosroshahi  1 , Zahra Haghshenas  2 , Arya Afrooghe  3 , Elham Ahmadi  3 , Mahdieh Mousavi Torshizi  4
Affiliations
Case Reports

Ten-year follow-up report and neurologic sequelae in a case of neonatal severe primary hyperparathyroidism

Nahid Khosroshahi et al. Clin Case Rep. .

Abstract

We present a 10-year follow-up and describe our experience in managing a case of neonatal severe primary hyperparathyroidism (NSHPT) for the first time in Iran. Microcephaly, mental retardation, and epilepsy may be long time sequels of NSHPT. The brain MRI findings are compatible with an old hypoxic-ischemic event.

Keywords: epilepsy; mental retardation; microcephaly; neonatal severe primary hyperparathyroidism.

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Conflict of interest statement

There is no conflict of interest to declare.

Figures

FIGURE 1
FIGURE 1
Axial‐flair view: Periventricular abnormal hyperintensities.
FIGURE 2
FIGURE 2
Sagital‐T2: Thinning of corpus callosum.
FIGURE 3
FIGURE 3
Axial‐flair: Bilateral perirolandic and occipital hyperintensities.
See this image and copyright information in PMC

References

    1. Marx SJ, Sinaii N. Neonatal severe hyperparathyroidism: novel insights from calcium, PTH, and the CASR gene. J Clin Endocrinol Metab. 2020;105(4):1061‐1078. - PMC - PubMed
    1. Abdullayev T, Korkmaz M, Kul M, Koray N. A rare cause of neonatal hypercalcemia: neonatal severe primary hyperparathyroidism: a case report and review of the literature. Int J Surg Case Rep. 2020;66:365‐369. - PMC - PubMed
    1. Özgüç Çömlek F, Demir S, Gürkan H, et al. The efficiency of cinacalcet treatment in delaying parathyroidectomy in a case with neonatal severe hyperparathyroidism caused by homozygous mutation in the CASR gene. Pediatr Endocrinol Diabetes Metab. 2022;28(2):168‐174. - PMC - PubMed
    1. Fisher MM, Cabrera SM, Imel EA. Successful treatment of neonatal severe hyperparathyroidism with cinacalcet in two patients. Endocrinol Diabetes Metab Case Rep. 2015;2015:150040. - PMC - PubMed
    1. Capozza M, Chinellato I, Guarnieri V, et al. Case report: acute clinical presentation and neonatal management of primary hyperparathyroidism due to a novel CaSR mutation. BMC Pediatr. 2018;18(1):340. - PMC - PubMed

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