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Case Reports
. 2023 Jul 10:10:1215389.
doi: 10.3389/fcvm.2023.1215389. eCollection 2023.

Cardiac osteosarcoma: a case report and literature review

Dae-Hwan Bae  1 , Sangshin Park  1 , Min Kim  1 , Sangmin Kim  1   2 , Woong Gil Choi  1   2 , Jang-Whan Bae  1   2 , Kyung-Kuk Hwang  1   2 , Dong-Woon Kim  1   2 , Myeong-Chan Cho  1 , Ju-Hee Lee  1
Affiliations
Case Reports

Cardiac osteosarcoma: a case report and literature review

Dae-Hwan Bae et al. Front Cardiovasc Med. .

Abstract

Background: Primary cardiac tumors are rare, and malignant primary cardiac tumors are even rarer. Cardiac osteosarcoma is a very rare type of malignant primary cardiac tumor with limited reported cases. We present a case report of cardiac osteosarcoma and review its characteristics and the related literature.

Case summary: A 44-year-old female patient without a specific medical history presented with intermittent dyspnea that started 1 month prior to presentation. A heterogeneous mass was observed in the left atrium on echocardiography and a large mass was observed in the left atrium on computed tomography. Surgery was performed under the suspicion of atypical cardiac myxoma, and the tumor was successfully removed. However, postoperative histopathological examination revealed cardiac osteosarcoma. The patient underwent chemotherapy and has been well maintained without recurrence for 10 years.

Conclusion: We present a case report of the echocardiographic features and treatment strategies for cardiac osteosarcoma, an extremely rare cardiac tumor. Multimodal imaging can be helpful; however, a histological diagnosis through surgical resection is essential. Appropriate treatment and follow-up based on histological findings are necessary.

Keywords: cardiac osteosarcoma; cardiac tumor; chemotherapy; echocardiography; surgery.

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Conflict of interest statement

The authors declare that the research was conducted in the absence of any commercial or financial relationships that could be construed as a potential conflict of interest.

Figures

Figure 1
Figure 1
(A) Transthoracic echocardiography, parasternal long axis view. A broad-based mass is filling the left atrium and protruding into the LV cavity during diastole. (B) Transesophageal echocardiography, systole. The mass which is composed of three different parts are shown. (C) Transesophageal echocardiography, diastole. The mixed portion of the mass is protruding into the LV cavity during diastole. (D) Thoracoabdominal computed tomography reveals an intracardiac mass occupying the left atrium. LV, left ventricle.
Figure 2
Figure 2
Gross photograph of the mass. (A,B) A 7 cm × 5 cm × 4 cm sized huge mass with multilobulated one hard portion and two cystic portion was surgically removed.
Figure 3
Figure 3
Photomicrograph of the mass. (A) The cellular anaplastic area is mixed with cartilage and atypical cells (hematoxylin and eosin staining, X100). (B) Atypical pleomorphic osteoblasts are observed, and a cellular anaplastic area with cartilage is present (hematoxylin and eosin staining, X400).
See this image and copyright information in PMC

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