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Review
. 2022 Sep 5;10(5):1956-1968.
doi: 10.1016/j.gendis.2022.08.015. eCollection 2023 Sep.

The Janus-faced role of Piezo1 in cardiovascular health under mechanical stimulation

Junyang Huang  1 , Kun Zhang  1 , Ruolin Du  1 , Wanling Liu  1 , Haijun Zhang  2 , Tian Tian  1 , Yazhou Wang  3 , Guixue Wang  1 , Tieying Yin  1
Affiliations
Review

The Janus-faced role of Piezo1 in cardiovascular health under mechanical stimulation

Junyang Huang et al. Genes Dis. .

Abstract

In recent years, cardiovascular health problems are becoming more and more serious. At the same time, mechanical stimulation closely relates to cardiovascular health. In this context, Piezo1, which is very sensitive to mechanical stimulation, has attracted our attention. Here, we review the critical significance of Piezo1 in mechanical stimulation of endothelial cells, NO production, lipid metabolism, DNA damage protection, the development of new blood vessels and maturation, narrowing of blood vessels, blood pressure regulation, vascular permeability, insulin sensitivity, and maintenance of red blood cell function. Besides, Piezo1 may participate in the occurrence and development of atherosclerosis, diabetes, hypertension, and other cardiovascular diseases. It is worth noting that Piezo1 has dual effects on maintaining cardiovascular health. On the one hand, the function of Piezo1 is necessary to maintain cardiovascular health; on the other hand, under some extreme mechanical stimulation, the overexpression of Piezo1 may bring adverse factors such as inflammation. Therefore, this review discusses the Janus-faced role of Piezo1 in maintaining cardiovascular health and puts forward new ideas to provide references for gene therapy or nanoagents targeting Piezo1.

Keywords: Atherosclerosis; Cardiovascular disease; Endothelial cells (ECs); Mechanical stimulation; Piezo1.

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Figures

Fig. 1
Figure 1
Threshold of Piezo1.
Fig. 2
Figure 2
The role of Piezo1 upon mechanical stimulation.,,, Piezo1 promotes NO release under laminar flow; Piezo1 regulates the release of NF-κB under disturbed flow; Piezo1 mediates vasoconstriction during exercise.
Fig. 3
Figure 3
The Yin and Yang of Piezo1 in common cardiovascular diseases.
See this image and copyright information in PMC

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