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Review
. 2023 Jul 23;4(4):e325.
doi: 10.1002/mco2.325. eCollection 2023 Aug.

The double-edged role of neutrophil heterogeneity in inflammatory diseases and cancers

Wencheng Zhou  1 , Xinran Cao  2 , Qiang Xu  2 , Jiao Qu  2 , Yang Sun  2
Affiliations
Review

The double-edged role of neutrophil heterogeneity in inflammatory diseases and cancers

Wencheng Zhou et al. MedComm (2020). .

Abstract

Neutrophils are important immune cells act as the body's first line of defense against infection and respond to diverse inflammatory cues. Many studies have demonstrated that neutrophils display plasticity in inflammatory diseases and cancers. Clarifying the role of neutrophil heterogeneity in inflammatory diseases and cancers will contribute to the development of novel treatment strategies. In this review, we have presented a review on the development of the understanding on neutrophil heterogeneity from the traditional perspective and a high-resolution viewpoint. A growing body of evidence has confirmed the double-edged role of neutrophils in inflammatory diseases and tumors. This may be due to a lack of precise understanding of the role of specific neutrophil subsets in the disease. Thus, elucidating specific neutrophil subsets involved in diseases would benefit the development of precision medicine. Thusly, we have summarized the relevance and actions of neutrophil heterogeneity in inflammatory diseases and cancers comprehensively. Meanwhile, we also discussed the potential intervention strategy for neutrophils. This review is intended to deepen our understanding of neutrophil heterogeneity in inflammatory diseases and cancers, while hold promise for precise treatment of neutrophil-related diseases.

Keywords: cancers; inflammatory diseases; neutrophil extracellular traps; neutrophil heterogeneity; single‐cell sequencing.

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Conflict of interest statement

The authors have no conflicts of interest to declare.

Figures

FIGURE 1
FIGURE 1
Schematic representation of the neutrophil heterogeneity in inflammatory diseases and cancers (in blue). This figure is created with BioRender.com.
FIGURE 2
FIGURE 2
Development of understanding of neutrophils. This figure is created with BioRender.com.
FIGURE 3
FIGURE 3
Neutrophils show both proinflammation activity or anti‐inflammation capacities. This figure is created with BioRender.com.
FIGURE 4
FIGURE 4
Neutrophil heterogeneity in inflammatory diseases. This figure is created with BioRender.com.
FIGURE 5
FIGURE 5
Neutrophils show both protumor activity or antitumor capacities. This figure is created with BioRender.com.
FIGURE 6
FIGURE 6
Neutrophil heterogeneity in cancers. This figure is created with BioRender.com.
See this image and copyright information in PMC

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