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Review
. 2023 Sep;50(9):7839-7849.
doi: 10.1007/s11033-023-08611-1. Epub 2023 Jul 26.

Molecular and biological factors in the prognosis of head and neck squamous cell cancer

Sergei S Naumov  1 , Denis E Kulbakin  2 , Nadezhda V Krakhmal  3   2 , Sergey V Vtorushin  3   2
Affiliations
Review

Molecular and biological factors in the prognosis of head and neck squamous cell cancer

Sergei S Naumov et al. Mol Biol Rep. 2023 Sep.

Abstract

The objective of the review is to summarize available literary data on the role and prognostic value of molecular biological markers p53, UBE2C, CD147, STAT3, VEGF in the carcinogenesis of head and neck squamous cell carcinoma (HNSCC). To date, researches have been studying HNSCC molecular and genetic characteristics and obtaining information about new molecular biological markers that have different functional significance in tumor progression. This review presents current data on protein molecules involved in the HNSCC development, as well as in the formation of drug resistance mechanisms in tumors. The considered markers can be used not only for prognosis but also for developing a new approach to treatment, including patients resistant to therapy or recurrent HNSCC. However, the introduction of these markers into practice requires further examination of their functions and larger-scale studies.

Keywords: HNSCC; Molecular markers; Tumor progression.

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