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Review
. 2023 Sep;52(3):485-496.
doi: 10.1016/j.ecl.2023.01.004. Epub 2023 Mar 1.

Metabolic-Associated Fatty Liver Disease and the Gut Microbiota

Thomas M Barber  1 , Petra Hanson  2 , Martin O Weickert  3
Affiliations
Review

Metabolic-Associated Fatty Liver Disease and the Gut Microbiota

Thomas M Barber et al. Endocrinol Metab Clin North Am. 2023 Sep.

Abstract

As an important sequela of the burgeoning global obesity problem, metabolic-associated fatty liver disease (MAFLD) has gained increasing prominence recently. The gut-liver axis (GLA) provides a direct conduit to the liver for the gut microbiota and their metabolic by-products (including secondary bile acids, ethanol, and trimethylamine). These GLA-related factors, including the host inflammatory response and integrity of the gut mucosal wall, likely contribute to the pathogenesis of MAFLD. Accordingly, these GLA-related factors are targets for possible preventive and treatment strategies for MAFLD, and include probiotics, prebiotics, bile acids, short-chain fatty acids, fecal microbiota transplantation, carbon nanoparticles, and bacteriophages.

Keywords: Gut microbiota; Metabolic-associated fatty liver disease; Obesity.

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