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Comment
. 2023 Sep;9(9):703-704.
doi: 10.1016/j.trecan.2023.07.003. Epub 2023 Jul 25.

Digging deeper into the early steps of cancer progression

Jonathan H Sussman  1 , Ben Z Stanger  2
Affiliations
Comment

Digging deeper into the early steps of cancer progression

Jonathan H Sussman et al. Trends Cancer. 2023 Sep.

Abstract

Epigenetically mediated cell signaling is emerging as a core principle of tumor biology. Through single cell multi-omic profiling, Burdziak, Alonso-Curbelo et al. have recently uncovered key epigenetic plasticity programs associated with cellular communication, shedding light on the role of epigenetic cell states during malignant transformation of the inflamed pancreas.

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Conflict of interest statement

Declaration of interests No interests are declared.

Comment on

  • Epigenetic plasticity cooperates with cell-cell interactions to direct pancreatic tumorigenesis.
    Burdziak C, Alonso-Curbelo D, Walle T, Reyes J, Barriga FM, Haviv D, Xie Y, Zhao Z, Zhao CJ, Chen HA, Chaudhary O, Masilionis I, Choo ZN, Gao V, Luan W, Wuest A, Ho YJ, Wei Y, Quail DF, Koche R, Mazutis L, Chaligné R, Nawy T, Lowe SW, Pe'er D. Burdziak C, et al. Science. 2023 May 12;380(6645):eadd5327. doi: 10.1126/science.add5327. Epub 2023 May 12. Science. 2023. PMID: 37167403 Free PMC article.

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