Adult-onset Alexander disease with unusual inflammatory features and a novel GFAP mutation in two patients

Affiliations

¹ Department of Pathology, Waikato Hospital, Hamilton, New Zealand.
² Department of Neurology, Onze-Lieve-Vrouwziekenhuis, Aalst, Belgium.
³ Department of Neurology, Waikato Hospital, Hamilton, New Zealand.
⁴ Department of Radiology, University Hospital, Ghent, Belgium.
⁵ Pathology Queensland, Royal Brisbane and Women's Hospital, Herston, Australia.

Case Reports

Fouzia Ziad et al. Neuropathol Appl Neurobiol. 2023 Aug.

. 2023 Aug;49(4):e12927.

doi: 10.1111/nan.12927.

¹ Department of Pathology, Waikato Hospital, Hamilton, New Zealand.
² Department of Neurology, Onze-Lieve-Vrouwziekenhuis, Aalst, Belgium.
³ Department of Neurology, Waikato Hospital, Hamilton, New Zealand.
⁴ Department of Radiology, University Hospital, Ghent, Belgium.
⁵ Pathology Queensland, Royal Brisbane and Women's Hospital, Herston, Australia.

No abstract available

Keywords: Alexander disease; GFAP mutation; adult onset; inflammation.

References

1. Hagemann TL. Alexander disease: models, mechanisms, and medicine. Curr Opin Neurobiol. 2022;72:140-147. doi:10.1016/j.conb.2021.10.002
1. Pajares MA, Hernández-Gerez E, Pekny M, Pérez-Sala D. Alexander disease: the road ahead. Neural Regen Res. 2023;18(10):2156-2160. doi:10.4103/1673-5374.369097
1. Prust M, Wang J, Morizono H, et al. GFAP mutations, age at onset, and clinical subtypes in Alexander disease. Neurology. 2011;77(13):1287-1294. doi:10.1212/WNL.0b013e3182309f72
1. van der Knaap MS, Bugiani M. Leukodystrophies: a proposed classification system based on pathological changes and pathogenetic mechanisms. Acta Neuropathol. 2017;134(3):351-382. doi:10.1007/s00401-017-1739-1
1. Waisman Center. University of Wisconsin-Madison. Alexander disease. GFAP mutations associated with Alexander disease. Available at: http://www.waisman.wisc.edu/alexander-disease