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Review
. 2023 Jul 5;9(7):e17987.
doi: 10.1016/j.heliyon.2023.e17987. eCollection 2023 Jul.

Bibliometric analysis of global research on the role of apolipoprotein E in Alzheimer's disease

Zhanzhang Wang  1   2 , Xiuqing Zhu  1   2 , Yuguan Wen  1   2 , Dewei Shang  1   2
Affiliations
Review

Bibliometric analysis of global research on the role of apolipoprotein E in Alzheimer's disease

Zhanzhang Wang et al. Heliyon. .

Abstract

Alzheimer's disease (AD) has attracted considerable attention from the public and scientific researchers, leading to a rapid growth in relevant research on this disorder in the last 10 years. The present study aimed to conduct a bibliometric analysis to elucidate the trends of global research on the role of apolipoprotein E in AD in the past decade. Three bibliometric software (CiteSpace, VOSviewer, and R Bibliometrix) were used to analyze the active journals, countries/regions, institutes, authors, co-cited references, and keywords in this field. The USA was the most influential country, and the University of California was the most productive institute. Zetterberg H contributed the highest number of publications, and Petersen RC was the most cited author in this field. On the basis of the co-cited reference analysis, knowledge base on biomarkers, risk factors, and mechanisms were updated in the past decade. Current research hotspots are shifting to tau-related mechanisms and identification of genetic risk factors. Our study provides insights into the developing knowledge base and trends related to research on apolipoprotein E in AD, which may provide new directions for further research in this field.

Keywords: Alzheimer's disease; Apolipoprotein E; Biomarker; Mechanism; Risk factor.

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Conflict of interest statement

The authors declare that they have no known competing financial interests or personal relationships that could have appeared to influence the work reported in this paper.

Figures

Fig. 1
Fig. 1
Distribution and growth trends of documents and citations on APOE in AD from 2011 to 2021.
Fig. 2
Fig. 2
Number of documents (A) and cooperation networks (B) of active countries/regions in this field.
Fig. 3
Fig. 3
Co-citation networks of major institutes (A) and authors (B).
Fig. 4
Fig. 4
Top 25 references with the strongest citation burst (A). Top 12 co-citation clusters of references with the highest connected components and their landmark references in cluster view (B) and timeline view (C).
Fig. 5
Fig. 5
Cluster maps of keywords in three visualizations: network (A), overlay (B), and density (C). Top 25 keywords with the strongest citation burst (D).
See this image and copyright information in PMC

References

    1. Dubois B., Villain N., Frisoni G.B., Rabinovici G.D., Sabbagh M., Cappa S., et al. Clinical diagnosis of Alzheimer's disease: recommendations of the international working Group. Lancet Neurol. 2021;20(6):484–496. doi: 10.1016/s1474-4422(21)00066-1. - DOI - PMC - PubMed
    1. Alzheimer's Association Alzheimer's disease facts and figures. Alzheimers Dement. 2022;18(4):700–789. doi: 10.1002/alz.12638. - DOI - PubMed
    1. Serrano-Pozo A., Aldridge G.M., Zhang Q. Four decades of research in Alzheimer's disease (1975-2014): a bibliometric and scientometric analysis. J. Alzheimers Dis. 2017;59(2):763–783. doi: 10.3233/jad-170184. - DOI - PMC - PubMed
    1. Hasel P., Liddelow S.A. Isoform-dependent APOE secretion modulates neuroinflammation. Nat. Rev. Neurol. 2021;17(5):265–266. doi: 10.1038/s41582-021-00483-y. - DOI - PubMed
    1. Serrano-Pozo A., Das S., Hyman B.T. APOE and Alzheimer's disease: advances in genetics, pathophysiology, and therapeutic approaches. Lancet Neurol. 2021;20(1):68–80. doi: 10.1016/s1474-4422(20)30412-9. - DOI - PMC - PubMed

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