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. 2023 Jul;35(129):227-230.
doi: 10.22038/IJORL.2023.65286.3238.

Multifocal Langerhans' Cell Histiocytosis in an Adult

Navid Nourizadeh  1 , Mohammad Reza Majidi  1 , Mohammad Reza Afzalzadeh  1 , Shirin Taraz Jamshidi  2
Affiliations

Multifocal Langerhans' Cell Histiocytosis in an Adult

Navid Nourizadeh et al. Iran J Otorhinolaryngol. 2023 Jul.

Abstract

Introduction: Multifocal Langerhans' cell histocytosis is a rare condition that can affect multiple organs and manifest in various scenarios. While the condition is more commonly found in children, it can also occur in adults.

Case report: A 43-year-old female presented with refractory otorrhea and had a rubbery neck mass in the left mid-cervical area, as well as an itchy eczematoid lesion in the left parietal area. The otic lesion was eventually resected, and histopathologic examination confirmed the diagnosis of Langerhans histiocytosis.

Conclusions: Although rare in adults, Langerhans histiocytosis should be considered as one of the differential diagnoses for ear canal polyps. If diagnosed, medical treatment should be pursued.

Keywords: Langerhans’ Cell Histiocytosis; Mastoiditis; Neck mass.

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Figures

Fig 1
Fig 1
Left seborrhoic rash on left parietal region
Fig 2
Fig 2
Occluded ear canal with polypoid tissue and obscured eardrum
Fig 3
Fig 3
A left-sided mobile nontender 3*3 neck mass with a rubbery texture
Fig 4
Fig 4
Coronal temporal CT scan shows sclerotic left mastoid due to chronic matoiditis and soft tissue density in mastoid middle ear and external auditary
Fig 5
Fig 5
A. H&E (Hematoxylin and Eosin) staining of infiltrated histiocytes with round to oval nuclei having nuclear clefts and adequate cytoplasmic appearance, along with some eosinophils scattered throughout.B. Immunohistochemical staining with anti-CD1a antibody showing positive results.C. Immunohistochemical staining with S100 marker showing positive results
See this image and copyright information in PMC

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