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. 2023 Jun 12;14(7):3225-3233.
doi: 10.1364/BOE.489708. eCollection 2023 Jul 1.

Enhanced 3D visualization of human fallopian tube morphology using a miniature optical coherence tomography catheter

Hongbo Luo  1 , Shuying Li  2 , Sitai Kou  2 , Yixiao Lin  2 , Ian S Hagemann  3   4 , Quing Zhu  1   2   5
Affiliations

Enhanced 3D visualization of human fallopian tube morphology using a miniature optical coherence tomography catheter

Hongbo Luo et al. Biomed Opt Express. .

Abstract

We demonstrate the use of our miniature optical coherence tomography catheter to acquire three-dimensional human fallopian tube images. Images of the fallopian tube's tissue morphology, vasculature, and tissue heterogeneity distribution are enhanced by adaptive thresholding, masking, and intensity inverting, making it easier to differentiate malignant tissue from normal tissue. The results show that normal fallopian tubes tend to have rich vasculature accompanied by a patterned tissue scattering background, features that do not appear in malignant cases. This finding suggests that miniature OCT catheters may have great potential for fast optical biopsy of the fallopian tube.

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Conflict of interest statement

The authors declare no conflicts of interest.

Figures

Fig. 1.
Fig. 1.
(a). Ex vivo fallopian tube sample and 3D OCT scan locations. Figures 1 (b-g) Steps in generating intensity inverted 3D images: (b) An original 3D OCT image of a fallopian tube fimbriae section, displayed at a random angle with ImageJ 3Dviewer. (c) An original OCT B-scan image. (d) Adaptive thresholding applied to enhance contrast. (e) Masking applied to extract the signal region. (f) Signal intensity inverting applied. (g) 3D view of the intensity inverted image.
Fig. 2.
Fig. 2.
3D OCT scans from the fimbriae section.
Fig. 3.
Fig. 3.
3D OCT scans from the infundibulum section.
Fig. 4.
Fig. 4.
One 3D OCT scan from the ampulla section.
Fig. 5.
Fig. 5.
Directionality analysis: (a) Fimbriated section, and (b) Infundibulum.
See this image and copyright information in PMC

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