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. 2024 May;30(4):2645-2652.
doi: 10.1111/odi.14695. Epub 2023 Jul 27.

Determination of serum and gingival crevicular fluid levels of omentin in healthy and rheumatoid arthritis subjects with and without periodontitis

Jyothi Mohit  1 , Geetha Ari  1 , Jaideep Mahendra  1 , Prashanthi Prakash  1 , Muskan Bedi  2 , Pavithra H Dave  1 , Anitha Logaranjani  1 , Ambalavanan Namasivayam  1
Affiliations

Determination of serum and gingival crevicular fluid levels of omentin in healthy and rheumatoid arthritis subjects with and without periodontitis

Jyothi Mohit et al. Oral Dis. 2024 May.

Abstract

Objective: The aim of this study was to assess and correlate the serum and GCF levels of omentin with the periodontal status of rheumatoid arthritis (RA) patients with and without periodontitis.

Methods: Forty-four patients were divided into four groups: group H: 11 systemically and periodontally healthy subjects; group P: 11 systemically healthy subjects with periodontitis; group RA: 11 periodontally healthy subjects with rheumatoid arthritis and group RA + P: 11 rheumatoid arthritis subjects with periodontitis. Periodontal parameters (plaque index, modified gingival index, probing depth, and clinical attachment level) were recorded and serum and GCF samples were collected for the estimation of omentin using ELISA.

Results: The mean value of plaque index, modified gingival index, probing depth, and clinical attachment level were significantly higher whereas serum and GCF omentin levels were found to be decreased in group IV when compared to the other groups. The significant correlation was found between the serum and GCF omentin levels with all the periodontal parameters.

Conclusion: The omentin level in serum and GCF was found to be lower in RA patients with periodontitis. It is also inversely correlated with the periodontal parameters. Thus, omentin can serve as a significant diagnostic and therapeutic tool in both periodontal and rheumatoid disease.

Keywords: GCF; adipokines; biomarkers; omentin; periodontitis; rheumatoid arthritis; serum.

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References

REFERENCES

    1. Angelotti, F., Parma, A., Cafaro, G., Capecchi, R., Alunno, A., & Puxeddu, I. (2017). One year in review 2017: Pathogenesis of rheumatoid arthritis. Clinical and Experimental Rheumatology, 35(3), 368–378.
    1. Bagwe, S., Gopalakrishnan, D., Mehta, V., Mathur, A., Kapare, K., & Deshpande, A. (2020). GCF and serum levels of omentin in periodontal health and disease of diabetic and non‐diabetic individuals: A comparative study. Indian Journal of Dental Research, 31(4), 520–525.
    1. Balli, U., Dogan, S. B., Dede, F. O., Sertoglu, E., & Keles, G. C. (2016). The levels of visceral adipose tissue‐derived serpin, omentin‐1 and tumor necrosis factor‐α in the gingival crevicular fluid of obese patients following periodontal therapy. Journal of Oral Science, 58(4), 465–473.
    1. Bello‐Gualtero, J. M., Lafaurie, G. I., Hoyos, L. X., Castillo, D. M., De‐Avila, J., Munevar, J. C., Unriza, S., Londoño, J., Valle‐Oñate, R., & Romero‐Sánchez, C. (2016). Periodontal disease in individuals with a genetic risk of developing arthritis and early rheumatoid arthritis: A cross‐sectional study. Journal of Periodontology, 87(4), 346–356.
    1. Carrión, M., Frommer, K. W., Pérez‐García, S., Müller‐Ladner, U., Gomariz, R. P., & Neumann, E. (2019). The adipokine network in rheumatic joint diseases. International Journal of Molecular Sciences, 20(17), 4091. https://doi.org/10.3390/ijms20174091

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