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Case Reports
. 2023 Jul;3(3):87-93.
doi: 10.47936/encephalitis.2023.00010. Epub 2023 Jun 27.

Intrathecal tigecycline is a safe and effective treatment for central nervous system infections

Antonio Mastroianni  1 , Valeria Vangeli  1 , Maria Vittoria Mauro  2 , Filippo Urso  3 , Roberto Manfredi  4 , Sonia Greco  1
Affiliations
Case Reports

Intrathecal tigecycline is a safe and effective treatment for central nervous system infections

Antonio Mastroianni et al. Encephalitis. 2023 Jul.

Abstract

Both the safety and effectiveness of intrathecal tigecycline (TGC) for treatment of infections of the central nervous system (CNS) are discussed using the clinical findings from a study of a recent patient who came to our attention, along with a literature review. Although penetration into the CNS is low (approximately 11%), intraventricular TGC could help treat patients with severe post- neurosurgical CNS infections. The use of multiple routes of TGC administration appears to be encouraging and should be considered in managing life-threatening intraventricular infections.

Keywords: Central nervous system bacterial infections; Intrathecal injections; Multi drug resistance; Tigecycline.

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Conflict of interest statement

Conflicts of Interest

No potential conflict of interest relevant to this article was reported.

References

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