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Comment
. 2023 Sep;39(9):716-717.
doi: 10.1016/j.pt.2023.07.003. Epub 2023 Jul 25.

Indole metabolites generated by microbiota inhibit Cryptosporidium growth

Jan R Mead  1
Affiliations
Comment

Indole metabolites generated by microbiota inhibit Cryptosporidium growth

Jan R Mead. Trends Parasitol. 2023 Sep.

Abstract

Funkhouser-Jones et al. recently identified gut metabolites that affected Cryptosporidium growth. A key focus, indole, was shown to inhibit the parasite in vivo and in vitro by decreasing the host mitochondria function and the membrane potential of parasite mitosomes. These findings help clarify the role microflora and metabolites play in host resistance.

Keywords: Cryptosporidium; indole; metabolites; microbiota.

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Conflict of interest statement

Declaration of interests The author declares no competing interests.

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