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Clinical Trial
. 1986 Sep 13;70(6):325-8.

Epidural fentanyl in the management of postoperative pain

E A Shipton, J M Hugo, F O Müller
  • PMID: 3750135
Clinical Trial

Epidural fentanyl in the management of postoperative pain

E A Shipton et al. S Afr Med J. .

Abstract

Epidural fentanyl (Sublimaze; Janssen) in the management of postoperative pain, with particular attention to efficacy and safety, was investigated. A treatment group (group 1) of 31 patients and a control group (group 2) of 30 patients were used. Group 1 received epidural fentanyl 100 micrograms postoperatively, while in the control group pain was treated with intramuscular pethidine 1.5 mg/kg 4-6-hourly as required during the 11 hours in the recovery room. Epidural fentanyl started working within 20 minutes and provided excellent analgesia for 8 hours or more postoperatively, comparable to repeated doses of intramuscular pethidine. Of the patients in group 1 13% experienced tolerable pruritus and the incidence of nausea and vomiting was small relative to that recorded in group 2.

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