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Review
. 2023 Jun;9(2):95-105.
doi: 10.5114/ceh.2023.128633. Epub 2023 Jun 21.

Significant roles of potential genes and their mutations in nonalcoholic fatty liver disease

Babak Sokouti  1
Affiliations
Review

Significant roles of potential genes and their mutations in nonalcoholic fatty liver disease

Babak Sokouti. Clin Exp Hepatol. 2023 Jun.

Abstract

In addition to having inflammation in the liver, overweight people also have changes in the composition of their immune systems and subsets of their immune systems. There are several genes involved in liver metabolism that have been implicated in nonalcoholic fatty liver disease (NAFLD), a liver disease associated with obesity, which is caused by high triglycerides and liver transaminases. NAFLD, a global liver disease, may differ in gene expression depending on where a person lives. In some alleles, the risk factors were independent. Finally, the researchers identified many genetic variations connected to fatty liver disease in those who did not drink alcohol regularly. These variants were located in genes involved in RNA metabolism, protein catabolism, and energy metabolism.

Keywords: genetic; metabolism; mutation; nonalcoholic fatty liver disease.

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Conflict of interest statement

The authors declare no conflict of interest.

Figures

Fig. 1
Fig. 1
How fatty liver disease develops and what variables increase the likelihood of developing NAFLD and NASH
See this image and copyright information in PMC

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