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Review
. 2023 Jun;9(2):95-105.
doi: 10.5114/ceh.2023.128633. Epub 2023 Jun 21.

Significant roles of potential genes and their mutations in nonalcoholic fatty liver disease

Babak Sokouti  1
Affiliations
Review

Significant roles of potential genes and their mutations in nonalcoholic fatty liver disease

Babak Sokouti. Clin Exp Hepatol. 2023 Jun.

Abstract

In addition to having inflammation in the liver, overweight people also have changes in the composition of their immune systems and subsets of their immune systems. There are several genes involved in liver metabolism that have been implicated in nonalcoholic fatty liver disease (NAFLD), a liver disease associated with obesity, which is caused by high triglycerides and liver transaminases. NAFLD, a global liver disease, may differ in gene expression depending on where a person lives. In some alleles, the risk factors were independent. Finally, the researchers identified many genetic variations connected to fatty liver disease in those who did not drink alcohol regularly. These variants were located in genes involved in RNA metabolism, protein catabolism, and energy metabolism.

Keywords: genetic; metabolism; mutation; nonalcoholic fatty liver disease.

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Conflict of interest statement

The authors declare no conflict of interest.

Figures

Fig. 1
Fig. 1
How fatty liver disease develops and what variables increase the likelihood of developing NAFLD and NASH
See this image and copyright information in PMC

References

    1. Tilg H, Moschen A. Update on nonalcoholic fatty liver disease: genes involved in nonalcoholic fatty liver disease and associated inflammation. Curr Opin Clin Nutr Metab Care 2010; 13: 391-396. - PubMed
    1. Santoro N, Feldstein AE, Enoksson E, et al. The association between hepatic fat content and liver injury in obese children and adolescents: effects of ethnicity, insulin resistance, and common gene variants. Diabetes Care 2013; 36: 1353-1360. - PMC - PubMed
    1. Weber M, Mera P, Casas J, et al. Liver CPT1A gene therapy reduces diet-induced hepatic steatosis in mice and highlights potential lipid biomarkers for human NAFLD. FASEB J 2020; 34: 11816-11837. - PubMed
    1. Orellana-Gavaldà JM, Herrero L, Malandrino MI, et al. Molecular therapy for obesity and diabetes based on a long-term increase in hepatic fatty-acid oxidation. Hepatology 2011; 53: 821-832. - PubMed
    1. Monsénégo J, Mansouri A, Akkaoui M, et al. Enhancing liver mitochondrial fatty acid oxidation capacity in obese mice improves insulin sensitivity independently of hepatic steatosis. J Hepatol 2012; 56: 632-639. - PubMed