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. 2023 Jul 26;6(2):249-260.
doi: 10.3138/canlivj-2022-0030. eCollection 2023 Jul.

Annual trends of hepatitis C virus infection in Manitoba between 1998 and 2018: A focus on special populations

Sai Krishna Gudi  1 , Sherif Eltonsy  1 , Joseph Delaney  1   2 , Carla Osiowy  3   4 , Carole Taylor  4 , Kelly Kaita  4   5   6 , Silvia Alessi-Severini  1
Affiliations

Annual trends of hepatitis C virus infection in Manitoba between 1998 and 2018: A focus on special populations

Sai Krishna Gudi et al. Can Liver J. .

Abstract

Background: Hepatitis C virus (HCV) infection is a major cause of liver-related morbidity and mortality worldwide. Epidemiological data of HCV infection in the Canadian province of Manitoba are limited.

Methods: A population-based retrospective study was conducted using data from the Manitoba Centre for Health Policy repository. Using the test results provided by the Cadham provincial laboratory, individuals in Manitoba with a diagnosis of HCV infection were identified. Annual prevalence and incidence rates (crude and standardized) were calculated for the overall population and stratified by sex, regional health authority (RHA), residence area, income quintile, and special population groups (children, older adults, and pregnant persons).

Results: A total of 8,721 HCV cases were diagnosed between 1998 and 2018 in Manitoba. Overall crude HCV incidence and prevalence were estimated as 0.03% and 0.37% during the study period, respectively. No significant change was observed in the standardized HCV incidence rate (per 100,000) during the study period (54.3 in 1998 and 54.8 in 2018). However, the standardized HCV prevalence (per 100,000) increased from 52.5 (95% CI 39.2-68.7) in 1998 to 655.2 (95% CI 605.9-707.3) in 2018. An overall average incidence rate based on sex, RHA, region, income, and special population groups was observed to be higher in males (40.1), Winnipeg RHA (42.7), urban region (42.3), low-income quintiles (78.5), and pregnant persons (94.3), respectively.

Conclusion: Although incidence rates of HCV infection in Manitoba appeared to have initially declined, rates showed an upward trend by the end of the study period while prevalence increased steadily.

Keywords: Manitoba; children; hepatitis C; incidence; older adults; pregnant persons; prevalence.

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Conflict of interest statement

SK Gudi received funding from the Drug Safety and Effectiveness Cross-Disciplinary Training (DSECT) program, as well as meeting support from the Canadian Network for Observational Drug Effect Studies (CNODES). C Osiowy received registration and accommodation for the Canadian Liver Meeting 2022 in Ottawa for being a speaker at the meeting. S Alessi-Severini was awarded the Leslie F. Buggey Professorship, which supported the present manuscript. She also received consulting fees from Jupiter Research Inc.

Figures

Figure 1:
Figure 1:
Time-trends in hepatitis C virus annual incidence by sex (a) and regional health authority (b)
Figure 2:
Figure 2:
Time-trends in hepatitis C virus annual incidence by region (a) and income quintile (b)
Figure 3:
Figure 3:
Time-trends in hepatitis C virus annual incidence by special population groups
See this image and copyright information in PMC

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