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. 2023 Mar;24(2):76-84.
doi: 10.5152/ThoracResPract.2023.22130.

Effect of Continuous Positive Airway Pressure Therapy on Pro-Brain Natriuretic Peptide, C-Reactive Protein, Homocysteine, and Cardiac Markers in Patients with Obstructive Sleep Apnea

Nejdiye Güngördü  1 , Şermin Börekçi  1 , Hazal Cansu Çulpan  2 , Erkam Coşkun  3 , Faruk Ayan  4 , Birsen Mutlu  1
Affiliations

Effect of Continuous Positive Airway Pressure Therapy on Pro-Brain Natriuretic Peptide, C-Reactive Protein, Homocysteine, and Cardiac Markers in Patients with Obstructive Sleep Apnea

Nejdiye Güngördü et al. Thorac Res Pract. 2023 Mar.

Abstract

Objective: Obstructive sleep apnea is associated with increased morbidity and mortality, especially cardiovascular and cerebrovascular, and affects a significant proportion of the population. The study was aimed to determine the levels of pro-brain natriuretic peptide, C-reactive protein, homocysteine, and cardiac markers (creatine kinase, creatine kinase isoenzyme MB, troponin T) and evaluate the effectiveness of continuous positive airway pressure therapy in patients with obstructive sleep apnea.

Material and methods: Pro-brain natriuretic peptide, C-reactive protein, homocysteine, and cardiac markers (creatine kinase, creatine kinase isoenzyme MB, troponin T) were assessed in blood samples collected before and after continuous positive airway pressure treatment from the 30 patients included in the study, and their results were compared.

Results: There was a significant decrease between the baseline pro-brain natriuretic peptide and the 6-month pro-brain natriuretic peptide values after continuous positive airway pressure therapy (P < .05). There was a significant increase in creatine kinase-MB and troponin T values 6 months after continuous positive airway pressure therapy compared to baseline values (P < .05).

Conclusions: A significant decrease was observed in pro-brain natriuretic peptide values after continuous positive airway pressure therapy in obstructive sleep apnea patients without cardiac failure, while a more significant decrease was especially observed among hypertension patients. This finding suggests that pro-brain natriuretic peptide may be used as an early indicator of cardiac dysfunction in obstructive sleep apnea patients without any heart diseases except for hypertension.

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Figures

Figure 1.
Figure 1.
Comparison of baseline and 6-month pro-brain natriuretic peptide, C-reactive protein, homocysteine, and cardiac biomarkers after continuous positive airway pressure treatment by apnea–hypopnea index groups.
Figure 2.
Figure 2.
Comparison of baseline and 6-month pro-brain natriuretic peptide, C-reactive protein, homocysteine, and cardiac biomarkers after continuous positive airway pressure treatment by the presence of hypertension.
See this image and copyright information in PMC

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