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Review
. 2023 Jun 30;13(7):694.
doi: 10.3390/bios13070694.

Multivariate Optimization of Electrochemical Biosensors for the Determination of Compounds Related to Food Safety-A Review

Héctor Fernández  1 , María Alicia Zon  1 , Sabrina Antonella Maccio  1 , Rubén Darío Alaníz  1 , Aylen Di Tocco  1 , Roodney Alberto Carrillo Palomino  1 , Jose Alberto Cabas Rodríguez  1 , Adrian Marcelo Granero  1 , Fernando J Arévalo  1 , Sebastian Noel Robledo  1   2 , Gastón Darío Pierini  1
Affiliations
Review

Multivariate Optimization of Electrochemical Biosensors for the Determination of Compounds Related to Food Safety-A Review

Héctor Fernández et al. Biosensors (Basel). .

Abstract

We summarize the application of multivariate optimization for the construction of electrochemical biosensors. The introduction provides an overview of electrochemical biosensing, which is classified into catalytic-based and affinity-based biosensors, and discusses the most recent published works in each category. We then explore the relevance of electrochemical biosensors for food safety analysis, taking into account analytes of different natures. Then, we describe the chemometrics tools used in the construction of electrochemical sensors/biosensors and provide examples from the literature. Finally, we carefully discuss the construction of electrochemical biosensors based on design of experiments, including the advantages, disadvantages, and future perspectives of using multivariate optimization in this field. The discussion section offers a comprehensive analysis of these topics.

Keywords: chemometrics tools; design of experiments; electrochemical biosensors; food safety; multivariate optimization.

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Conflict of interest statement

The authors declare no conflict of interest.

Figures

Figure 1
Figure 1
Schematic representation of the number of papers published for developed electrochemical biosensors according to the analyte related to food safety.
Figure 2
Figure 2
A typical design of an enzyme modified electrochemical biosensor.
Scheme 1
Scheme 1
Sequential steps for the construction of an electrochemical biosensor using a glassy carbon electrode.
See this image and copyright information in PMC

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