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Review
. 2023 Jun 30;45(7):5575-5597.
doi: 10.3390/cimb45070352.

Pathology and Molecular Biology of Melanoma

Tanase Timis  1   2 , Jon Thor Bergthorsson  3 , Victor Greiff  4 , Mihai Cenariu  5 , Diana Cenariu  6
Affiliations
Review

Pathology and Molecular Biology of Melanoma

Tanase Timis et al. Curr Issues Mol Biol. .

Abstract

Almost every death in young patients with an advanced skin tumor is caused by melanoma. Today, with the help of modern treatments, these patients survive longer or can even achieve a cure. Advanced stage melanoma is frequently related with poor prognosis and physicians still find this disease difficult to manage due to the absence of a lasting response to initial treatment regimens and the lack of randomized clinical trials in post immunotherapy/targeted molecular therapy settings. New therapeutic targets are emerging from preclinical data on the genetic profile of melanocytes and from the identification of molecular factors involved in the pathogenesis of malignant transformation. In the current paper, we present the diagnostic challenges, molecular biology and genetics of malignant melanoma, as well as the current therapeutic options for patients with this diagnosis.

Keywords: clinical implications; genetics; melanoma; molecular biology.

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Conflict of interest statement

The authors declare no conflict of interest.

References

    1. Arnold M., Singh D., Laversanne M., Vignat J., Vaccarella S., Meheus F., Cust A.E., de Vries E., Whiteman D.C., Bray F. Global Burden of Cutaneous Melanoma in 2020 and Projections to 2040. JAMA Dermatol. 2022;158:495503. doi: 10.1001/jamadermatol.2022.0160. - DOI - PMC - PubMed
    1. Matthews N.H., Li W.Q., Qureshi A.A., Weinstock M.A., Cho E. Epidemiology of Melanoma. In: Ward W.H., Farma J.M., editors. Cutaneous Melanoma: Etiology and Therapy. Codon Publications; Brisbane, AU, Australia: 2017. [(accessed on 5 May 2023)]. Chapter 1. Available online: https://www.ncbi.nlm.nih.gov/books/NBK481862/ - DOI - PubMed
    1. Hall H., Miller D.R., Rogers J.D., Bewerse B. Update on the incidence and mortality from melanoma in the United States. [(accessed on 5 May 2023)];J. Am. Acad. Dermatol. 1999 40:35–42. doi: 10.1016/S0190-9622(99)70562-1. Available online: https://www.sciencedirect.com/science/article/pii/S0190962299705621. - DOI - PubMed
    1. Roh M.R., Eliades P., Gupta S., Grant-Kels J.M., Tsao H. Cutaneous melanoma in women. Int. J. Womens Dermatol. 2017;3:S11–S15. doi: 10.1016/j.ijwd.2017.02.003. - DOI - PMC - PubMed
    1. Bharath A., Turner R. Impact of climate change on skin cancer. J. R. Soc. Med. 2009;102:215–218. doi: 10.1258/jrsm.2009.080261. - DOI - PMC - PubMed

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