Skip to main page content
U.S. flag

An official website of the United States government

Dot gov

The .gov means it’s official.
Federal government websites often end in .gov or .mil. Before sharing sensitive information, make sure you’re on a federal government site.

Https

The site is secure.
The https:// ensures that you are connecting to the official website and that any information you provide is encrypted and transmitted securely.

Access keys NCBI Homepage MyNCBI Homepage Main Content Main Navigation
Review
. 2023 Jun 29;9(7):530.
doi: 10.3390/gels9070530.

Green Synthesis of Silver Nanoparticles Loaded Hydrogel for Wound Healing; Systematic Review

Fahad M Aldakheel  1   2 , Marwa M El Sayed  3 , Dalia Mohsen  4   5 , Mohammed H Fagir  4 , Dalia K El Dein  4
Affiliations
Review

Green Synthesis of Silver Nanoparticles Loaded Hydrogel for Wound Healing; Systematic Review

Fahad M Aldakheel et al. Gels. .

Abstract

Wound healing is a biological process that involves a series of consecutive process, and its impairment can lead to chronic wounds and various complications. Recently, there has been a growing interest in employing nanotechnology to enhance wound healing. Silver nanoparticles (AgNPs) have expanded significant attention due to their wide range of applications in the medical field. The advantages of AgNPs include their easy synthesis, change their shape, and high surface area. Silver nanoparticles are very efficient for topical drug administration and wound healing because of their high ratio of surface area to volume. The efficiency of AgNPs depends on the synthesis method and the intended application. Green synthesis methods offer an eco-friendly approach by utilizing natural sources such as plant extracts and fungus. The characterization of nanoparticles plays an important character, and it is accomplished through the use of several characterization methods such as UV-Vis spectroscopy, Fourier transform infrared spectroscopy (FT-IR), scanning electron microscopy (SEM), transmission electron microscopy (TEM), and X-ray diffraction (XRD). These techniques are employed to confirm the specific characters of the prepared Silver Nanoparticles. Additionally, the review addresses the challenges and future perspectives of utilizing green-synthesized AgNPs loaded in Polyacrylamide hydrogel for wound healing applications, including the optimization of nanoparticle size, and release kinetics. Overall, this review highlights the potential of green-synthesized AgNPs loaded in Polyacrylamide hydrogel as promising for advanced wound healing therapies. There are different approaches of usage of AgNPs for wound healing such as polyacrylamide -hydrogels, and the mechanism after their antibacterial action, have been exposed.

Keywords: characterization methods; green synthesis; polyacrylamide hydrogel; silver nanoparticles; wound healing.

PubMed Disclaimer

Conflict of interest statement

The authors declare no conflict of interest.

Figures

Figure 1
Figure 1
Different techniques used for the synthesis of silver nanoparticles.
Figure 2
Figure 2
Schematic representation of the green synthesis production of silver nanoparticles (Ag NPs) using bacteria, fungus, and/or plants.
Figure 3
Figure 3
The summary of the characterization methods used for silver nanoparticles.
Figure 4
Figure 4
PRISMA (Preferred Reporting Items for Systematic Reviews and Meta-Analysis).
See this image and copyright information in PMC

Similar articles

See all similar articles

Cited by

See all "Cited by" articles

References

    1. Augustine R., Kalarikkal A., Thomas S. PCL membranes incorporated with biosynthesized silver nanoparticles as antibacterial wound dressings. Appl. Nanosci. 2016;6:337–344. doi: 10.1007/s13204-015-0439-1. - DOI
    1. García-Villén F., Faccendini A., Aguzzi C., Cerezo P., Bonferoni M.C., Rossi S., Grisoli P., Ruggeri M., Ferrari F., Sandri G., et al. Montmorillonite-Norfloxacin nanocomposite intended for healing of infected wounds. Int. J. Nanomed. 2019;14:5051–5060. doi: 10.2147/IJN.S208713. - DOI - PMC - PubMed
    1. Pang S., Gao Y., Wang F., Wang Y., Cao M., Zhang W., Liang Y., Song M., Jiang G. Toxicity of silver nanoparticles on wound healing: A case study of zebrafish fin regeneration model. Sci. Total Environ. 2020;10:717. doi: 10.1016/j.scitotenv.2020.137178. - DOI - PubMed
    1. Satarupa B., Kumari V., Shatabdi D., Moumita., Dutta D.M., Jyotsna M., Sandhimita M., Arnab G. Antibacterial, anti-biofilm activity and mechanism of action of pancreatin doped zinc oxide nanoparticles against methicillin resistant Staphylococcus aureus. Colloid Surf. B Biointerfaces. 2020;11:190. - PubMed
    1. Kardan-Yamchi J., Kazemian H., Battaglia S., Abtahi H., Foroushani A.R., Hamzelou G., Cirillo D.M., Ghodousi A., Feizabadi M.M. Whole genome sequencing results associated with minimum inhibitory concentrations of 14 anti-tuberculosis drugs among rifampicin-resistant isolates of mycobacterium tuberculosis from Iran. J. Clin. Med. 2020;9:465. doi: 10.3390/jcm9020465. - DOI - PMC - PubMed

LinkOut - more resources