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. 2023 Jul 24;13(7):686.
doi: 10.3390/membranes13070686.

Safety and Effectiveness of Carbon Dioxide Removal CO2RESET Device in Critically Ill Patients

Fabio Silvio Taccone  1 , Simone Rinaldi  2 , Filippo Annoni  1 , Leda Nobile  1 , Matteo Di Nardo  3 , Jessica Maccieri  2 , Anna Aliberti  4 , Maximilan Valentin Malfertheiner  5 , Andrea Marudi  2 , Lars Mikael Broman  6   7 , Mirko Belliato  4
Affiliations

Safety and Effectiveness of Carbon Dioxide Removal CO2RESET Device in Critically Ill Patients

Fabio Silvio Taccone et al. Membranes (Basel). .

Abstract

Background: In this retrospective study, we report the effectiveness and safety of a dedicated extracorporeal carbon dioxide removal (ECCO2R) device in critically ill patients.

Methods: Adult patients on mechanical ventilation due to acute respiratory distress syndrome (ARDS) or decompensated chronic obstructive pulmonary disease (dCOPD), who were treated with a dedicated ECCO2R device (CO2RESET, Eurosets, Medolla, Italy) in case of hypercapnic acidemia, were included. Repeated measurements of CO2 removal (VCO2) at baseline and 1, 12, and 24 h after the initiation of therapy were recorded.

Results: Over a three-year period, 11 patients received ECCO2R (median age 60 [43-72] years) 3 (2-39) days after ICU admission; nine patients had ARDS and two had dCOPD. Median baseline pH and PaCO2 levels were 7.27 (7.12-7.33) and 65 (50-84) mmHg, respectively. With a median ECCO2R blood flow of 800 (500-800) mL/min and maximum gas flow of 6 (2-14) L/min, the VCO2 at 12 h after ECCO2R initiation was 157 (58-183) mL/min. Tidal volume, respiratory rate, and driving pressure were significantly reduced over time. Few side effects were reported.

Conclusions: In this study, a dedicated ECCO2R device provided a high VCO2 with a favorable risk profile.

Keywords: ARDS; CO2 removal; complications; extracorporeal; high blood flow; respiratory failure.

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Conflict of interest statement

F.S.T., M.D.N., M.B., L.M.B. and M.V.M. are on the Advisory Board of EUROSETS srl.

Figures

Figure 1
Figure 1
Representation of the CO2RESET device (left) and the membrane lung (right).
Figure 2
Figure 2
CO2 removal (VCO2) over time. * indicates significant differences with baseline values.
Figure 3
Figure 3
Tidal volume, respiratory rate, and driving pressure change over time. * indicates significant differences with baseline values.
See this image and copyright information in PMC

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