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Review
. 2023 Jun 30;11(7):571.
doi: 10.3390/toxics11070571.

Research Progress on Neurodevelopmental Toxicity in Offspring after Indirect Exposure to PFASs in Early Life

Huai-Yu Zhuchen  1 , Jie-Yu Wang  1 , Xiao-Shan Liu  2 , Yan-Wei Shi  1   3   4
Affiliations
Review

Research Progress on Neurodevelopmental Toxicity in Offspring after Indirect Exposure to PFASs in Early Life

Huai-Yu Zhuchen et al. Toxics. .

Abstract

Per- and polyfluoroalkyl substances (PFASs) are widespread environmental pollutants. There is increasing evidence that PFASs have various adverse health effects, including renal toxicity, metabolic dysfunction, endocrine disruption, and developmental toxicity. PFASs have been found to accumulate in the placenta, and some PFASs can cross the placental barrier and subsequently accumulate in the fetus via the maternal-fetal circulation. An increasing number of studies have shown that early life exposure to PFASs can affect fetal neurodevelopment. This paper reviews the characteristics of indirect exposure to PFASs in early life, the effects on neurodevelopment in offspring, and the possible mechanisms of toxic effects.

Keywords: PFAS; developmental neurotoxicity; early life exposure; placenta.

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Conflict of interest statement

The authors declare no conflict of interest.

Figures

Figure 1
Figure 1
Mechanisms of neurodevelopmental toxicity after exposure to PFAS in early life.
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